Recombinant Anti-CMV gB (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone 1/22 x Clone 2/4)
CAT#: VS-0525-YC36
The recombinant Anti-CMV gB (N-terminus x C-terminus) biparatopic antibody, tandem scFv (Clone 1/22 x Clone 2/4), is structured to bind two unique epitopes of the CMV gB protein. The antibody design includes a tandem scFv, where the 1/22 scFv binds the N-terminal portion (NETIYNTTLKYGDV) and is fused N-terminally to the 2/4 scFv that binds the C-terminal portion (VTSGSTKD).
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- CMV gB
- Species Reactivity
- HCMV
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 1/22
- Clone 2
- 2/4
- Epitope 1
- N-terminus of gB, NETIYNTTLKYGDV
- Epitope 2
- C-terminus of gB, VTSGSTKD
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, WB
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Cytomegalovirus glycoprotein B
Target
- Introduction
- Cytomegalovirus (CMV), is a genus of Herpes viruses; in humans the species is known as Human herpesvirus 5 (HHV-5). It belongs to the Betaherpesvirinae subfamily of Herpesviridae. The name means "very big cell virus". Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Participates also in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
- Alternative Names
- CMV gB; Cytomegalovirus glycoprotein B; HCMV; HCMV glycoprotein B; HHV-5; Human herpesvirus 5; UL55
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Datasheet
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