This product is a humanized antibody targeting collagen. This antibody has specific binding activity for a cryptic collagen epitope, including inhibiting angiogenesis, tumor growth, and metastasis.
Figure 1 Shows the activity and specificity of HUI77 variants. The binding of purified Fabs of IX-177, containing wild type HUI77 CDRs, and HUI77 variants Qh2b-B7 and QhuD9 is shown for denatured collagen I.
Figure 2 Shows the effect of the HUI77 variant QH2b on B16 melanoma cell proliferation.
B16 melanoma cells grown in culture were not treated (control; squares) or treated with the IgG form of the QH2b variant (circles).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-228 | Recombinant Anti-Collagen Antibody | WB, FC, FuncS | IgG |
MHH-228 | Recombinant Human Anti-Collagen Antibody | WB, Dot, FuncS | IgG |
MOB-0299MZ | Recombinant Mouse Anti-Human Collagen IV Antibody (clone DIV 23 (2)) | IHC | Mouse antibody |
HPAB-1166WJ | Human Anti-Collagen Recombinant Antibody (clone HUIV26) | ELISA, IF, DB, Inhib | Humanized IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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