Rabbit Anti-CR1 Recombinant Antibody (VS13-YC242)
CAT#: VS13-YC242
The Rabbit Anti-CR1 Recombinant Antibody is specific for human CR1. CR1, a complement receptor, interacts with immune components, aiding in defense against conditions like malaria through pathways affecting blood group interactions. The anti-CR1 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Normal Tissue
Figure 1 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49348/115721_A_9_5.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49348/115721_A_8_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49348/115721_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (HL-60, HMC-1, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000203710-CR1
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Specifications
- Immunogen
- Recombinant human CD35.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CR1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
- Related Disease
- Malaria and Plasmodium Falciparum Malaria
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS only
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Complement C3b/C4b Receptor 1 (Knops Blood Group); Complement Component (3b/4b) Receptor 1 (Knops Blood Group); C3b/C4b Receptor; CD35 Antigen; C3BR; Complement Component (3b/4b) Receptor 1, Including Knops Blood Group System; Complement Component 3b/4b Receptor 1 (Knops Blood Group);
- Gene ID
- 1378
- UniProt ID
- P17927
- Long Name
- Complement C3b/C4b Receptor 1 (Knops Blood Group)
- Sequence Similarities
- Belongs to the receptors of complement activation (RCA) family.
- Cellular Localization
- Membrane
- Protein Refseq
- NP_000564.2; NP_000642.3
- Function
- Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069).
Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069).
Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d, g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757).
Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728).
(Microbial infection) Acts as a receptor for Epstein-Barr virus.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| MOB-240-S(P) | Recombinant Anti-human CR1 Antibody scFv Fragment | WB, FC, FuncS | scFv |
| MHH-240-S(P) | Recombinant Human Anti-human CR1 Antibody scFv Fragment | Neut, WB, FuncS | scFv |
| HPAB-0421-CN-S(P) | Mouse Anti-CR1 Recombinant Antibody (clone E11); scFv Fragment | ELISA, FC | Mouse scFv |
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| CAT | Product Name | Application | Type |
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| MHH-240-F(E) | Recombinant Human Anti-human CR1 Antibody Fab Fragment | ELISA, Nert, FuncS | Fab |
| HPAB-0421-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone E11); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0422-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone EDIVH1/VL1); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0423-CN-F(E) | Mouse Anti-CR1 Recombinant Antibody (clone EDI19E9); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0424-CN-F(E) | Human Anti-CR1 Recombinant Antibody (clone EDI3G4); Fab Fragment | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0284MZ | Recombinant Mouse Anti-Human Complement Component (3b/4b) Receptor 1 (Knops blood group) Antibody (clone Cer-MAC-DRC1) | IHC | Mouse antibody |
| HPAB-0421-CN | Mouse Anti-CR1 Recombinant Antibody (clone E11) | ELISA, FC | Mouse IgG1 |
| HPAB-0422-CN | Mouse Anti-CR1 Recombinant Antibody (clone EDIVH1/VL1) | ELISA, FC | Mouse IgG1 |
| FAMAB-0310-CN | Mouse Anti-CR1 Recombinant Antibody (clone HB8592) | ELISA | Mouse IgG |
| ZG-0621J | Rabbit Anti-CR1 Recombinant Antibody (clone 9A9) | ELISA, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-496CQ | Mouse Anti-CR1 Recombinant Antibody (NEUT-496CQ) | Block, ELISA, FC, IHC-Fr, IHC-P | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0794 | Hi-Affi™ Rabbit Anti-CR1 Recombinant Antibody (clone DS794AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY93 | Mouse Anti-NHP CR1 Recombinant Antibody (clone E11) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY535 | Anti-CR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1647 | Anti-Mouse CR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1649 | Anti-Human CR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC567 | Recombinant Anti-CR1 Vesicular Antibody, EV Displayed (VS-0425-YC567) | ELISA, FC, Cell-uptake |
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