Mouse Anti-CRTC1 Recombinant Antibody (VS3-FY2675) (CAT#: VS3-FY2675)
The anti-CRTC1 antibody is a mouse IgG recombinant monoclonal antibody, which has been specifically designed to bind the human CRTC1 protein. The monoclonal antibody can be suitable for use in Western Blot, Immunocytochemistry, Flow cytometry, Immunoprecipitation assays.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/187_C10_1_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear bodies, plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/187_C10_1_selected.jpg
Figure 2 Cerebellum
(High expression in cerebellum)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_B_7_8_val_selected.jpg
(High expression in cerebellum)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_B_7_8_val_selected.jpg
Figure 3 Testis
(Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_4_6.jpg
(Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_4_6.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_B_8_5.jpg
Figure 5 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_9_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_9_3.jpg
Figure 6 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_7_4.jpg
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22035/48988_A_7_4.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105662-CRTC1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105662-CRTC1
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- CREB regulated transcription coactivator 1 of human
- Species Reactivity
- Human
- Applications
- WB, ICC, FC, IP
- Conjugate
- Unconjugated, FITC
- Related Disease
- Mucoepidermoid Carcinoma and Clear Cell Hidradenoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Immunocytochemistry: 1/50-1/200
Flow cytometry: 1/50-1/100
Target
- Alternative Names
- CREB Regulated Transcription Coactivator 1; Mucoepidermoid Carcinoma Translocated Protein 1; TORC-1; WAMTP1; MECT1; TORC1; Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 1
- Gene ID
- 23373
- UniProt ID
- Q6UUV9
- Sequence Similarities
- Belongs to the TORC family.
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity.
TORCs are inactive when phosphorylated, and active when dephosphorylated at this site.
This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
Ubiquitination at Lys47
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001091952.1; NP_056136.2
- Function
- Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.
Enhances the interaction of CREB1 with TAF4.
Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.
Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1017CT | Recombinant Mouse anti-Human CRTC1 Monoclonal antibody (2C6) | ELISA, FC, ICC/IF, WB | |
| VS3-QX281 | Mouse Anti-CRTC1 Recombinant Antibody (clone 1B5) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS4-WK125 | Mouse Anti-CRTC1 Recombinant Antibody (VS4-WK125) | ELISA, WB, ICC, FC | Mouse IgG2b |
| VS7-HM773 | Mouse Anti-CRTC1 Recombinant Antibody (clone CBL176HM) | WB, IF, ICC, FCM, ELISA | Mouse IgG |
| VS7-HM774 | Mouse Anti-CRTC1 Recombinant Antibody (clone CBL177HM) | WB, FCM, IF, ICC | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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