Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0177-FY-S(P))

Name: Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0177-FY-S(P))
SKU: HPAB-0177-FY-S(P)
Rating: 5 (1 reviews)

CAT#: HPAB-0177-FY-S(P)

This product is a recombinant human antibody that recognizes colony stimulating factor 1 receptor. Single-chain antibody (scFv) is a small molecule composed of antibody heavy chain (VH) variable region and light chain (VL) variable region connected by a short linker peptide, which is not actually a fragment of an antibody, but instead is a fusion protein. The antibody binds to both human and cynomolgus monkey CSFIR ECD, but not to mouse CSFIR ECD.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/201_C4_2_selected.jpg

Normal Tissue Figure 2 IHC staining of human hippocampus

Immunohistochemical staining of human hippocampus shows cytoplasmic positivity in neuronal cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/29746_B_7_6_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_B_9_5.jpg

Normal Tissue Figure 4 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_3.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_6_6.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (BEWO, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182578-CSF1R

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Specifications

Host Species
Human

Derivation
Humanized

Type
Human scFv

Specificity
Human CSF1R

Species Reactivity
Human

Applications
Block

Related Disease
Multiple Sclerosis

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Colony Stimulating Factor 1 Receptor; McDonough Feline Sarcoma Viral (V-Fms) Oncogene Homolog; Proto-Oncogene C-Fms; CSF-1 Receptor; CD115 Antigen; EC 2.7.10.1; M-CSF-R; CSF-1R; FMS; Macrophage Colony Stimulating Factor I Receptor

Gene ID
1436

UniProt ID
P07333

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0177-FY-S(P).pdf

MSDS

MSDS - HPAB-0177-FY-S(P).pdf

COA

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