Anti-CSF3R Antibody Prodrug, Protease Activated (LMM-741)
CAT#: VS-1025-YC43
The Anti-CSF3R Antibody Prodrug, Protease Activated (LMM-741) is an antibody prodrug comprised of a recombinant mouse antibody targeting human CSF3R, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to CSF3R protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to CSF3R effectively. CSF3R (Colony Stimulating Factor 3 Receptor), or G-CSFR, is a receptor whose activating mutations are found in a subset of neutrophil-associated malignancies, most notably chronic neutrophilic leukemia (CNL). These mutations cause constitutive, ligand-independent activation of downstream signaling pathways. This drives the overproduction and dysregulation of neutrophils, which characterizes the disease.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_B_9_5.jpg
Normal Tissue
Figure 2 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_6_6.jpg
Normal Tissue
Figure 3 Placenta
Syncytiotrophoblasts - cell body
Staining:High
Intensity: Strong
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17116/37869_A_1_7.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (BEWO, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000119535-CSF3R
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human CSF3R
- Target
- CSF3R
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Clone
- LMM-741
- Epitope
- G-CSFR-ECD
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- G-CSFR is a cytokine that controls the production, differentiation, and function of granulocytes. It may also function in some cell surface adhesion or recognition processes.
- Alternative Names
- Colony Stimulating Factor 3 Receptor; G-CSF Receptor; CD114 Antigen; G-CSF-R; GCSFR; Granulocyte Colony-Stimulating Factor Receptor; CD114; SCN7; LMM-741
- Gene ID
- 1441
- UniProt ID
- Q99062
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone LMM-741"
- CAT
- Product Name
See other products for "CSF3R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-722-sdAb | Recombinant Anti-Human CSF3R VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1808z | Mouse Anti-CSF3R Recombinant Antibody (clone 28F2) | WB, ELISA, FC, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0140CT | Recombinant Mouse anti-Human CSF3R Monoclonal antibody (MNN886) | FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-548CQ | Rat Anti-Csf3r Recombinant Antibody (VMC178) | Neut | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-549CQ | Rat Anti-Csf3r Recombinant Antibody (clone CBL638) | Neut | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0829 | Hi-Affi™ Rabbit Anti-CSF3R Recombinant Antibody (clone DS829AB) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0081-YJ | Mouse Anti-CSF3R Recombinant Antibody (clone LMM-741) | FC, IP, WB | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC259 | CytoStream™ Rabbit Anti-CSF3R Recombinant Antibody (VS13-YC259) | FC, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC642 | Recombinant Anti-CSF3R Vesicular Antibody, EV Displayed (VS-0425-YC642) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1712 | Anti-CSF3R Immunohistochemistry Kit | IHC |
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