Chicken Anti-CTX Recombinant Antibody (clone S1)
CAT#: VS-0323-CJ10
This chicken anti-CTX antibody (clone S1) is a product that recognizes NNA venom Cytotoxin (CTX).
Published Data
ELISA
Figure 1 The ability of the two scFvs (VS-0323-CJ10 and VS-0323-CJ11) to bind to CTX was evaluated by indirect ELISA.
WB
Figure 2 The anti-CTX scFv S1 (VS-0323-CJ10) can specifically recognize CTX when tested against the major N. atra venom proteins.
Neut
Figure 3 Ability of anti-CTX S1 to neutralize the CTX-induced cytotoxicity toward C2C12 cells.
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Specifications
- Immunogen
- Attenuated CTX
- Host Species
- Chicken
- Type
- Chicken IgY
- Specificity
- NNA venom Cytotoxin (CTX)
- Species Reactivity
- NNA
- Clone
- S1
- Applications
- Enzyme-linked Immunosorbent Assay, Western Blot, Neutralization
- Conjugate
- Unconjugated
- Related Disease
- Snakebite
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Cytotoxin
- UniProt ID
- P60304
- Sequence Similarities
- Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
- Cellular Localization
- Membrane; Secreted; Target cell membrane; Target membrane
- Function
- Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity).
It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165).
It also binds with high affinity to heparin (PubMed:17685633).
It also causes skeletal muscle necrosis after intramuscular injection into mice (PubMed:8342169).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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Recommended Dilution Buffer
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See other products for "CTX"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-056 | Mouse Anti-CTX Recombinant Antibody (clone TE33) | ELISA, WB, FuncS | Mouse IgG |
| FAMAB-0078YC | Recombinant Human Anti-CTX Antibody (sc1) | ELISA | Human IgG |
| FAMAB-0079YC | Recombinant Human Anti-CTX Antibody (sc8) | ELISA | Human IgG |
| FAMAB-0080YC | Recombinant Human Anti-CTX Antibody (sc6) | ELISA | Human IgG |
| FAMAB-0142WJ | Camelid Anti-CTX Recombinant Antibody (clone LCTA9) | ELISA, Neut | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-056 | Mouse Anti-CTX Recombinant Antibody (clone TE33); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| FAMAB-0078-YC-S(P) | Recombinant Human Anti-CTX Antibody scFv Fragment (sc1) | ELISA | Human scFv |
| FAMAB-0079-YC-S(P) | Recombinant Human Anti-CTX Antibody scFv Fragment (sc8) | ELISA | Human scFv |
| FAMAB-0080-YC-S(P) | Recombinant Human Anti-CTX Antibody scFv Fragment (sc6) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-056 | Mouse Anti-CTX Recombinant Antibody (clone TE33); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| FAMAB-0078-YC-F(E) | Recombinant Human Anti-CTX Antibody Fab Fragment (sc1) | ELISA | Human Fab |
| FAMAB-0079-YC-F(E) | Recombinant Human Anti-CTX Antibody Fab Fragment (sc8) | ELISA | Human Fab |
| FAMAB-0080-YC-F(E) | Recombinant Human Anti-CTX Antibody Fab Fragment (sc6) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-033 | Recombinant Anti-cholera CTX VHH Single Domain Antibody (PNBL-033) | Inhib, FuncS | Llama VHH |
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