Anti-CXCL8 (clone 656.35) Recombinant Antibody Coupled Liposome (VS-1024-FY283)
CAT#: VS-1024-FY283
Anti-IL-8 antibody conjugated liposomes hold great potential in research for neovascular age-related macular degeneration (AMD) by specifically targeting inflammatory pathways that contribute to the disease's progression. This targeted approach may enhance the delivery of therapeutic agents directly to the site of pathology, potentially improving treatment efficacy and minimizing systemic side effects.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/1010_F11_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows moderate cytoplasmic positivity in non germinal center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line GAMG
Immunofluorescent staining of human cell line GAMG shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/2058_E8_1_blue_red_green.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/57179/131156_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169429-CXCL8
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Neovascular age-related macular degeneration (neovascular AMD)
Product Composition
- Clone
- 656.35
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody that was specifically engineered to target interleukin-8 (IL-8), a pro-inflammatory cytokine that plays a crucial role in various inflammatory processes and is implicated in several diseases. Through sophisticated biotechnology techniques, this antibody has been produced to ensure high specificity and affinity for IL-8, allowing it to effectively bind to and neutralize this cytokine.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CXCL8
- Introduction
- CXCL8 (C-X-C Motif Chemokine Ligand 8) is a Protein Coding gene. Diseases associated with CXCL8 include Bronchiolitis and Extrinsic Allergic Alveolitis. Among its related pathways are PEDF Induced Signaling and Bacterial infections in CF airways. Gene Ontology (GO) annotations related to this gene include chemokine activity and interleukin-8 receptor binding. An important paralog of this gene is PPBP.
- Alternative Names
- C-X-C Motif Chemokine Ligand 8; Monocyte-Derived Neutrophil Chemotactic Factor; Monocyte-Derived Neutrophil-Activating Peptide; Granulocyte Chemotactic Protein 1; Chemokine (C-X-C Motif) Ligand 8; Beta Endothelial Cell-Derived Neutrophil Activating Peptide; Lung Giant Cell Carcinoma-Derived Chemotactic Protein; Lymphocyte Derived Neutrophil Activating Peptide; Alveolar Macrophage Chemotactic Factor I; Tumor Necrosis Factor-Induced Gene 1; Neutrophil-Activating Peptide 1; T-Cell Chemotactic Factor; Interleukin 8; Emoctakin; GCP-1; MDNCF; MONAP
- Full Name
- C-X-C Motif Chemokine Ligand 8
- Gene ID
- 3576
- UniProt ID
- P10145
- Sequence Similarities
- Belongs to the intercrine alpha (chemokine CxC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells.
In general, IL-8(1-77) is referred to as interleukin-8.
IL-8(6-77) is the most promiment form.
- Protein Refseq
- NP_000575.1; NP_001341769.1
- Function
- Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, 7636208).
Also plays an important role in neutrophil activation (PubMed:2145175, 9623510).
Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY283. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 656.35"
- CAT
- Product Name
See other products for "CXCL8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-738-sdAb | Recombinant Anti-human CXCL8 VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201CL | Human Anti-CXCL8 Recombinant Antibody (TAB-201CL) | ELISA | Human IgG2 |
| TAB-701LC | Human Anti-CXCL8 Recombinant Antibody (TAB-701LC) | ELISA, FC, FuncS | Human IgG1, κ |
| TAB-701LC-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (TAB-701LC-S(P)) | ELISA | Human scFv |
| TAB-701LC-F(E) | Human Anti-CXCL8 Recombinant Antibody; Fab Fragment (TAB-701LC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-095LC | Recombinant Anti-Human CXCL8 Antibody (Fc glycosylation) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-164LC | Recombinant Anti-Human CXCL8 Antibody (Non-glycosylated) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-644CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL601) | ELISA, Neut | Mouse IgG1 |
| NEUT-645CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL602) | WB, ICC, Neut | Mouse IgG1 |
| NEUT-646CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone CBL115) | FC, WB, IHC, Neut | Mouse IgG1 |
| NEUT-647CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-60) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-648CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone I8-S2) | ELISA, Neut, WB | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-660CQ | Mouse Anti-CXCL8 Recombinant Antibody (clone B-K8) | Block, ICFC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4128 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone SI199DS) | ELISA | Rabbit IgG |
| MOR-4624 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH137DS) | WB | Rabbit IgG |
| MOR-4625 | Hi-Affi™ Rabbit Anti-CXCL8 Recombinant Antibody (clone TH138DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1973-CN | Rabbit Anti-CXCL8 Polyclonal Antibody (MRO-1973-CN) | ELISA, IF, IHC | Rabbit IgG |
| MRO-1974-CN | Rabbit Anti-CXCL8 Polyclonal Antibody (MRO-1974-CN) | WB, IF, FC | Rabbit IgG |
| HPAB-0664-YJ | Mouse Anti-CXCL8 Recombinant Antibody (clone 5.12.14) | ELISA, WB, Inhib, Antagonist | Mouse IgG2a |
| HPAB-0665-YJ | Human Anti-CXCL8 Recombinant Antibody (clone ch5.12.14) | ELISA, WB, Inhib, Antagonist | Chimeric (mouse/human) IgG1 |
| HPAB-1841-FY | Human Anti-CXCL8 Recombinant Antibody (clone WS-4) | Inhib, FC, ELISA, Block | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1682-FY-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (HPAB-1682-FY-S(P)) | ELISA | Human scFv |
| HPAB-1683-FY-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (HPAB-1683-FY-S(P)) | ELISA | Human scFv |
| HPAB-1684-FY-S(P) | Human Anti-CXCL8 Recombinant Antibody; scFv Fragment (HPAB-1684-FY-S(P)) | ELISA | Human scFv |
| HPAB-1310WJ-F(E) | Human Anti-CXCL8 Recombinant Antibody (clone M1-10); Fab Fragment | ELISA | Human Fab |
| HPAB-1311WJ-F(E) | Human Anti-CXCL8 Recombinant Antibody (clone M2-11); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1310WJ-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone M1-10); scFv Fragment | ELISA | Human scFv |
| HPAB-1311WJ-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone M2-11); scFv Fragment | ELISA | Human scFv |
| HPAB-1312WJ-S(P) | Human Anti-CXCL8 Recombinant Antibody (clone M1-3); scFv Fragment | ELISA | Human scFv |
| HPAB-1317WJ-S(P) | Recombinant Mouse Anti-CXCL8 Antibody scFv Fragment (5.12.14) | ELISA | Mouse scFv |
| HPAB-1318WJ-S(P) | Recombinant Mouse Anti-CXCL8 Antibody scFv Fragment (6G4.2.5) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY593 | Anti-CXCL8 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC86 | Recombinant Anti-CXCL8 Eliminating Antibody, pH-Sensitive (K2.2 var.) | Antigen-Sweeping In Vivo. | Human lgG2 |
See Our Custom Production in Action
Popular Products
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Block, Cyt, FuncS, Inhib
Application: ELISA, IP, WB, IHC, IF, FuncS
-3.png)
Application: ELISA, FC, Block, SPR
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
