Recombinant Anti-CXCR3 (AA 1-15 x AA 16-30) Biparatopic Antibody, Tandem scFv (Clone 1C6 x Clone 4B4)
CAT#: VS-0525-YC38
The recombinant Anti-CXCR3 (AA 1-15 x AA 16-30) biparatopic antibody, tandem scFv (Clone 1C6 x Clone 4B4), is designed to target two distinct sections on the CXCR3 receptor. This tandem scFv connects the 1C6 scFv, targeting amino acids 1-15, with the 4B4 scFv, which aims at amino acids 16-30, fused at the N-terminus.
Gene Expression
Normal Tissue
Figure 1 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_8_3.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_7_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_5_6.jpg
Normal Tissue
Figure 4 High expression in lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45942/139633_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186810-CXCR3
❮
❯
Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Mouse
- Specificity
- Human CXCR3
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- 1C6
- Clone 2
- 4B4
- Epitope 1
- aa 1-15
- Epitope 2
- aa 16-30
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, FC
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- C-X-C Motif Chemokine Receptor 3
Target
- Introduction
- This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
- Alternative Names
- Chemokine (C-X-C Motif) Receptor 3; G Protein-Coupled Receptor 9; Interferon-Inducible Protein 10 Receptor; IP-10 Receptor; CKR-L2; GPR9; CD183 Antigen; Mig Receptor; CMKAR3; IP10-R; CXC-R3; CXCR-3; CD182; CD183; Mig-R; MigR
- Gene ID
- 2833
- UniProt ID
- P49682
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Datasheet
MSDS
COA
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