Anti-CXCR4 (clone 5C9) Recombinant Antibody Coupled Liposome (VS-1024-FY49)
CAT#: VS-1024-FY49
Anti-CXCR4 antibody-conjugated liposomes represent a promising therapeutic approach for treating B-cell malignancies by specifically targeting the CXCR4 receptor, which is known to be overexpressed in a variety of cancers. This targeting strategy enhances the delivery of therapeutic agents directly to cancer cells, potentially increasing the efficacy of treatment while minimizing side effects on healthy tissues. By disrupting the CXCR4 signaling pathways that contribute to tumor growth and metastasis, these innovative liposomal formulations could significantly improve patient outcomes and provide a more effective option for managing these challenging malignancies.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
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More Infomation
Specifications
- Potential Clinical Applications
- B-cell malignancies
Product Composition
- Clone
- 5C9
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant monoclonal antibody derived from mice that specifically targets the chemokine receptor CXCR4. CXCR4 plays a crucial role in various biological processes, including immune responses, hematopoiesis, and the development of several diseases, particularly in cancer and HIV infection.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CXCR4
- Alternative Names
- C-X-C Motif Chemokine Receptor 4; Leukocyte-Derived Seven Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; Chemokine (C-X-C Motif) Receptor 4; LPS-Associated Protein 3; SDF-1 Receptor; CD184 Antigen; Fusin; LAP-3; LESTR; NPYRL; FB22; HM89; LCR1; Seven-Transmembrane-Segment Receptor, Spleen; Chemokine (C-X-C Motif), Receptor 4 (Fusin)
- Full Name
- C-X-C Motif Chemokine Receptor 4
- Gene ID
- 7852
- UniProt ID
- P61073
- Cellular Localization
- Cell membrane, Cell junction
- Post Translation Modifications
- Glycosylation at Asn11, Ser18, and Asn176 (NX_P61073 [NX_P61073-1])
Ubiquitination at Lys310, Lys327, and Lys331 (NX_P61073 [NX_P61073-1])
Modification sites at PhosphoSitePlus (P61073)
Glycosylation from GlyGen (P61073) 3 sites
- Protein Refseq
- XP_047301758.1; NP_001008540.1
- Function
- Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g.during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.
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Datasheet
MSDS
COA
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See other products for "Clone 5C9"
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- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0011CL-S(P) | Mouse Anti-CXCR4 Recombinant Antibody scFv Fragment (TAB-0011CL-S(P)) | FC, IHC, Block, Inhib, FuncS | |
| TAB-143MZ | Mouse Anti-CXCR4 Recombinant Antibody (TAB-143MZ) | Cyt, FuncS, Inhib | Mouse IgG1 |
| TAB-144MZ | Mouse Anti-CXCR4 Recombinant Antibody (TAB-144MZ) | Cyt, FuncS, Inhib | Mouse IgG1 |
| TAB-145MZ | Mouse Anti-CXCR4 Recombinant Antibody (TAB-145MZ) | Cyt, FC, FuncS, Inhib | Mouse IgG1 |
| TAB-149MZ | Mouse Anti-CXCR4 Recombinant Antibody (TAB-149MZ) | FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-142MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-142MZ) | ELISA | Human IgG1 |
| TAB-150MZ | Anti-Human CXCR4 Recombinant Antibody (CF172) | FC | Human antibody |
| TAB-151MZ | Anti-Human CXCR4 Recombinant Antibody (5C9) | FuncS | Human antibody |
| TAB-152MZ | Anti-Human CXCR4 Recombinant Antibody (5E1) | FuncS | Human antibody |
| TAB-153MZ | Anti-Human CXCR4 Recombinant Antibody (7C8) | FuncS, Inhib | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-146MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-146MZ) | Cyt, FuncS, Inhib | Humanized IgG1 |
| TAB-147MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-147MZ) | Cyt, FuncS, Inhib | Humanized IgG1 |
| TAB-148MZ | Human Anti-CXCR4 Recombinant Antibody (TAB-148MZ) | Cyt, FC, FuncS, Inhib | Humanized IgG1 |
| TAB-146MZ-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-146MZ-S(P)) | cAMP Assay | Humanized scFv |
| TAB-147MZ-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (TAB-147MZ-S(P)) | cAMP Assay | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0152MZ | Chicken Anti-CXCR4 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-684CQ | Mouse Anti-CXCR4 Recombinant Antibody (clone 12G5) | FC, CyTOF®, Neut | Mouse IgG2a |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0889 | Hi-Affi™ Rabbit Anti-CXCR4 Recombinant Antibody (clone DS889AB) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0044-YC-S(P) | Human Anti-CXCR4 Recombinant Antibody (clone hz515H7VH1D76NVL2); scFv Fragment | Block, Cyt, FC | Humanized scFv |
| HPAB-0045-YC-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-0045-YC-S(P)) | FC, Cyt | Humanized scFv |
| HPAB-1842-FY-F(E) | Human Anti-CXCR4 Recombinant Antibody (clone Ab124); scFv Fragment | Inhib | Human scFv |
| HPAB-1843-FY-F(E) | Human Anti-CXCR4 Recombinant Antibody (clone Ab125); scFv Fragment | Inhib | Human scFv |
| HPAB-2065-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-2065-FY-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0659-CN | Human Anti-CXCR4 Recombinant Antibody (HPAB-0659-CN) | FC, Neut | Human IgG |
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| HPAB-0661-CN | Human Anti-CXCR4 Recombinant Antibody (HPAB-0661-CN) | FC, Neut | Human IgG |
| HPAB-0685-WJ | Human Anti-CXCR4 Recombinant Antibody (HPAB-0685-WJ) | FC | Human IgG |
| HPAB-0686-WJ | Human Anti-CXCR4 Recombinant Antibody (HPAB-0686-WJ) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H72 | Afuco™ Anti-CXCR4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H72) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1685-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody (clone Hz515H7-VH1-D76N-VL2); Fab Fragment | ELISA, FC | Humanized Fab |
| HPAB-1686-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-1686-FY-S(P)) | FC | Human scFv |
| HPAB-1687-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-1687-FY-S(P)) | FC | Human scFv |
| HPAB-1688-FY-S(P) | Human Anti-CXCR4 Recombinant Antibody; scFv Fragment (HPAB-1688-FY-S(P)) | FC | Human scFv |
| HPAB-2065-FY-F(E) | Human Anti-CXCR4 Recombinant Antibody; Fab Fragment (HPAB-2065-FY-F(E)) | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1489 | AbPlus™ Anti-CXCR4 Magnetic Beads (VS-0724-YC1489) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0325-XY594 | Anti-CXCR4 Immunohistochemistry Kit | IHC | |
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| VS-0425-YC549 | Recombinant Anti-CXCR4 Vesicular Antibody, EV Displayed (VS-0425-YC549) | ELISA, FC, Neut, Cell-uptake |
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