Human Anti-CXCR4 Recombinant Antibody (clone C-9P21) (CAT#: HPAB-1504-FY)
This product is a recombinant antibody that recognizes CXCR4. The monoclonal antibody C-9P21 reacts with the epitope of CXCR4. The antibody is capable of inhibiting the binding of a ligand to CXCR4.
Specific Inquiry
Inhib
Figure 1 shows inhibition of ligand (SDF-1α) induced cell migration by anti-CXCR4 scFv C-9P21.
Human T-cell leukaemia CCRF-CEM cells labelled with BATDA were induced to migrate in Boyden chambers, where the SDF-1 ligand was placed in the lower chamber and the cells were co-incubated with antibodies or medium only as a control in the upper chambers.
Cyt
Figure 2 show the results of an assay to test the ability of the antibodies B-1M22, C-9P21, C-1I24, and D-1K21 to induce CDC.
Cyt
Figure 3 shows the induction of ADCC by the anti-CXCR4 antibodies B-1M22, C-9P21, C-1I24, and D-1K21.
Dose-response killing of CCRF-CEM cells is shown for scFvs C-9P21.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human CXCR4
- Species Reactivity
- Human
- Clone
- C-9P21
- Applications
- ELISA, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The CXCR4 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Inhibition, Cytotoxicity.
Target
- Alternative Names
- C-X-C Motif Chemokine Receptor 4; Leukocyte-Derived Seven Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; Chemokine (C-X-C Motif) Receptor 4; LPS-Associated Protein 3; SDF-1 Receptor; CD184 Antigen; Fusin; LAP-3; LESTR; NPYRL; FB22; HM89; LCR1; Seven-Transmembrane-Segment Receptor, Spleen; Chemokine (C-X-C Motif), Receptor 4 (Fusin)
- Gene ID
- 7852
- UniProt ID
- P61073
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1224z | Mouse Anti-CXCR4 Recombinant Antibody (clone 12B3) | FC, ICC, IHC, FuncS | Mouse IgG2a |
| MRO-1796-CN | Rabbit Anti-CXCR4 Polyclonal Antibody (MRO-1796-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-1842-FY | Human Anti-CXCR4 Recombinant Antibody (clone Ab124) | ELISA, FC, Inhib | Human IgG |
| HPAB-1843-FY | Human Anti-CXCR4 Recombinant Antibody (clone Ab125) | ELISA, FC, Inhib | Human IgG |
| VS-0723-WK67 | Human Anti-CXCR4 Recombinant Antibody (VS-0723-WK67) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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