Mouse Anti-CYLD Recombinant Antibody (VS3-FY2683) (CAT#: VS3-FY2683)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• CYLD lysine 63 deubiquitinase of human

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 107.3 kDa.

• Related Disease
• Cylindromatosis, Familial and Brooke-Spiegler Syndrome

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• CYLD Lysine 63 Deubiquitinase; Ubiquitin-Specific-Processing Protease CYLD; Cylindromatosis (Turban Tumor Syndrome); Ubiquitin Specific Peptidase Like 2; Deubiquitinating Enzyme CYLD; Ubiquitin Thioesterase CYLD; CYLD1; Probable Ubiquitin Carboxyl-Terminal Hydrolase CYLD; Ubiquitin Carboxyl-Terminal Hydrolase CYLD; Ubiquitin Thiolesterase CYLD; EC 3.4.19.12; EC 3.1.2.15

• Gene ID
• 1540

• Sequence Similarities
• Belongs to the peptidase C19 family.

• Cellular Localization
• Cytoplasm
  Cytoplasm, perinuclear region
  Cytoplasm, cytoskeleton
  Cell membrane; Peripheral membrane protein; Cytoplasmic side
  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  Cytoplasm, cytoskeleton, spindle
  Cytoplasm, cytoskeleton, cilium basal body

• Post Translation Modifications
• Ubiquitinated.
  Polyubiquitinated in hepatocytes treated with palmitic acid.
  Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.
  Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli.
  Phosphorylation requires IKBKG.
  Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.
  Ubiquitination at Lys10, Lys114, Lys121, Lys132, and Lys708
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_047289612.1; XP_047289614.1; XP_047289615.1; XP_047289616.1; XP_047289617.1

• Function
• Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, 20194890).
  Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, 19893491).
  Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086).
  Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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