Mouse Anti-CYLD Recombinant Antibody (VS3-FY2683)
CAT#: VS3-FY2683
The anti-CYLD product is a recombinant mouse monoclonal antibody that binds to CYLD protein, a calculated weight of 107.3 kDa. It cross-reacts with human. This monoclonal antibody is potential for conducting research on Cylindromatosis, Familial and Brooke-Spiegler Syndrome. The antibody can be utilized for detection of CYLD by Flow cytometry, ELISA.
| Sub Cat | Species Reactivity | Application | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2777 | Human | FC, ELISA |
Flow cytometry: 1/50-1/200 ELISA: 1/1000-1/10000 |
||||||
| VS3-FY2684 | Human, Mouse, Rat | WB, FC |
Western Blot: 1/500-1/2000 Flow cytometry: 1/10-1/25 |
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- CYLD lysine 63 deubiquitinase of human
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 107.3 kDa.
- Related Disease
- Cylindromatosis, Familial and Brooke-Spiegler Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CYLD Lysine 63 Deubiquitinase; Ubiquitin-Specific-Processing Protease CYLD; Cylindromatosis (Turban Tumor Syndrome); Ubiquitin Specific Peptidase Like 2; Deubiquitinating Enzyme CYLD; Ubiquitin Thioesterase CYLD; CYLD1; Probable Ubiquitin Carboxyl-Terminal Hydrolase CYLD; Ubiquitin Carboxyl-Terminal Hydrolase CYLD; Ubiquitin Thiolesterase CYLD; EC 3.4.19.12; EC 3.1.2.15
- Gene ID
- 1540
- Sequence Similarities
- Belongs to the peptidase C19 family.
- Cellular Localization
- Cytoplasm
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton
Cell membrane; Peripheral membrane protein; Cytoplasmic side
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, cilium basal body
- Post Translation Modifications
- Ubiquitinated.
Polyubiquitinated in hepatocytes treated with palmitic acid.
Ubiquitination is mediated by E3 ligase TRIM47 and leads to proteasomal degradation.
Phosphorylated on several serine residues by IKKA and/or IKKB in response to immune stimuli.
Phosphorylation requires IKBKG.
Phosphorylation abolishes TRAF2 deubiquitination, interferes with the activation of Jun kinases, and strongly reduces CD40-dependent gene activation by NF-kappa-B.
Ubiquitination at Lys10, Lys114, Lys121, Lys132, and Lys708
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047289612.1; XP_047289614.1; XP_047289615.1; XP_047289616.1; XP_047289617.1
- Function
- Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, 20194890).
Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, 19893491).
Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086).
Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CYLD"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1168 | Mouse Anti-CYLD Recombinant Antibody (VS3-WK1168) | WB, FC | Mouse IgG2a, κ |
| VS7-HM801 | Mouse Anti-CYLD Recombinant Antibody (clone 5F7F4) | FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY151 | Mouse Anti-NHP CYLD Recombinant Antibody (clone 733) | WB, IHC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1844 | Anti-CYLD Immunohistochemistry Kit | IHC |
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