Mouse Anti-CYP27B1 Recombinant Antibody (VS3-FY2685) (CAT#: VS3-FY2685)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Cytochrome P450 family 27 subfamily B member 1 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 56.5 kDa.

• Related Disease
• Vitamin D Hydroxylation-Deficient Rickets, Type 1A and Hypocalcemic Vitamin D-Dependent Rickets

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Cytochrome P450 Family 27 Subfamily B Member 1; Cytochrome P450, Family 27, Subfamily B, Polypeptide 1; Cytochrome P450 Subfamily XXVIIB Polypeptide 1; 25-OHD-1 Alpha-Hydroxylase; Calcidiol 1-Monooxygenase; Cytochrome P450VD1-Alpha; Cytochrome P450C1 Alpha; Cytochrome P450 27B1; VD3 1A Hydroxylase; 1alpha(OH)Ase; CYP1alpha; CYP27B; Cytochrome P450, Subfamily XXVIIB (25-Hydroxyvitamin D-1-Alpha-Hydroxylase), Polypeptide 1; 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial

• Gene ID
• 1594

• UniProt ID
• O15528

• Sequence Similarities
• Belongs to the cytochrome P450 family.

• Cellular Localization
• Mitochondrion membrane

• Post Translation Modifications
• Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_000776.1

• Function
• A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis.
  Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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