Mouse Anti-DAB2IP Recombinant Antibody (VS3-FY2686)
CAT#: VS3-FY2686
This anti-DAB2IP antibody is a mouse recombinant monoclonal antibody that is created to attach to DAB2IP protein, a calculated weight of 131.6 kDa. It exhibits cross-reactivity with human, mouse and rat. This monoclonal antibody is potential for conducting research on research of Medulloblastoma and Arteriosclerosis. The antibody can be utilized for detection of DAB2IP by Western Blot.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HaCaT, HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136848-DAB2IP
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- DAB2 interacting protein of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 131.6 kDa.
- Related Disease
- Medulloblastoma and Arteriosclerosis
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- DAB2 Interacting Protein; DOC-2/DAB2 Interactive Protein; ASK1-Interacting Protein 1; ASK-Interacting Protein 1; DAB2 Interaction Protein; NGAP-Like Protein; AF9Q34; AIP-1
- Gene ID
- 153090
- UniProt ID
- Q5VWQ8
- Cellular Localization
- Cytoplasm
Cell membrane; Peripheral membrane protein
Membrane
Cell projection, dendrite
- Post Translation Modifications
- In response to TNF-alpha-induction, phosphorylated at Ser-728; phosphorylation leads to a conformational change, and thus, increases its association with 14-3-3 proteins, MAP3K5, RIPK1 and TRAF2 in endothelial cells; also stimulates regulatory p85 subunit sequestring and PI3K-p85 complex activity inhibition.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001381939.1; NP_115941.2; NP_619723.1
- Function
- Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.
Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation.
Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest.
Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "DAB2IP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-174MZ | Anti-Human DAB2IP Recombinant Antibody | WB, IHC | |
| TAB-174MZ-S(P) | Anti-Human DAB2IP Recombinant Antibody scFv Fragment | WB, IHC | |
| TAB-174MZ-F(E) | Anti-Human DAB2IP Recombinant Antibody Fab Fragment | WB, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK1031 | Mouse Anti-DAB2IP Recombinant Antibody (VS3-WK1031) | WB | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY613 | Anti-DAB2IP Immunohistochemistry Kit | IHC |
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