Mouse Anti-DAB2IP Recombinant Antibody (VS3-FY2686) (CAT#: VS3-FY2686)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• DAB2 interacting protein of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 131.6 kDa.

• Related Disease
• Medulloblastoma and Arteriosclerosis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• DAB2 Interacting Protein; DOC-2/DAB2 Interactive Protein; ASK1-Interacting Protein 1; ASK-Interacting Protein 1; DAB2 Interaction Protein; NGAP-Like Protein; AF9Q34; AIP-1

• Gene ID
• 153090

• UniProt ID
• Q5VWQ8

• Cellular Localization
• Cytoplasm
  Cell membrane; Peripheral membrane protein
  Membrane
  Cell projection, dendrite

• Post Translation Modifications
• In response to TNF-alpha-induction, phosphorylated at Ser-728; phosphorylation leads to a conformational change, and thus, increases its association with 14-3-3 proteins, MAP3K5, RIPK1 and TRAF2 in endothelial cells; also stimulates regulatory p85 subunit sequestring and PI3K-p85 complex activity inhibition.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• NP_001381939.1; NP_115941.2; NP_619723.1

• Function
• Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.
  Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation.
  Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest.
  Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS).

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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