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  • Rabbit Anti-DBH Recombinant Antibody (clone R48-3P-5)

Rabbit Anti-DBH Recombinant Antibody (clone R48-3P-5) (CAT#: VS3-FY2194)

This dopamine beta hydroxylase antibody is a rabbit recombinant monoclonal antibody that specifically created to bind human DBH. It has been tested in WB and IHC assay. The R48-3P-5 is recommended for dilution of target protein by western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/100-1/200).


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Subcellular Location
Figure 1 IF staining of human cell line SH-SY5Y
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5960/1669_D6_1_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70789/1378_H2_4_selected.jpg
Normal Tissue
Figure 3 Adrenal gland
Figure 3 Adrenal gland
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2130/160606_B_4_5_val_selected.jpg
Figure 4 Colon
Figure 4 Colon
(Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70789/160599_A_7_3.jpg
Figure 5 Liver
Figure 5 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70789/160599_A_9_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (SH-SY5Y)
Figure 6 RNA cell line category: Cell line enriched (SH-SY5Y)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123454-DBH

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human DBH
  • Species Reactivity
  • Human
  • Clone
  • R48-3P-5
  • Applications
  • Western Blot, Immunohistochemistry-Paraffin
  • Conjugate
  • Unconjugated
  • MW
  • The calculated weight of the target protein is approximately 69 kDa, while the observed molecular weight stands at 70-75kDa.
  • Related Disease
  • Orthostatic Hypotension 1 and Dopamine Beta-Hydroxylase Deficiency

Product Property

  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl, 50% glycerol
  • Preservative
  • 0.02% Sodium azide
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000
    Immunohistochemistry: 1/100-1/200

Target

  • Alternative Names
  • Dopamine Beta-Hydroxylase; Dopamine Beta-Hydroxylase (Dopamine Beta-Monooxygenase); Dopamine Beta-Monooxygenase; EC 1.14.17.1; DBM
  • Sequence Similarities
  • Belongs to the copper type II ascorbate-dependent monooxygenase family.
  • Cellular Localization
  • Cytoplasmic vesicle, Membrane, Secreted
  • Post Translation Modifications
  • N-glycosylated. (P09172-DOPO_HUMAN)
    Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. (P09172-DOPO_HUMAN)
    Glycosylation at Asn64, Asn184, and Asn566 (NX_P09172 [NX_P09172-1])
    Modification sites at PhosphoSitePlus (P09172)
    Glycosylation from GlyConnect DOPO_HUMAN (1933)
    Glycosylation from GlyGen (P09172) 4 sites, 9 N-linked glycans (1 site)
  • Function
  • Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.

Recommended Products

Isotype Control

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "DBH"

Recombinant Antibody

CAT Product Name Application Type
MOB-2334z Mouse Anti-DBH Recombinant Antibody (clone 25D3) WB, ELISA, IF, IP Mouse IgG1, κ
MOB-0592CT Recombinant Mouse anti-Rat DBH Monoclonal antibody (9.G.405) ELISA, ICC, RID, WB

Immunotoxin

CAT Product Name Application Type
AGTO-L010S anti-DBH immunotoxin 4F10.2 (IgG)-Sap Cytotoxicity assay, Functional assay

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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