AbPlus™ Anti-DDB1 Magnetic Beads (VS-0724-YC888)
CAT#: VS-0724-YC888
The AbPlus Anti-DDB1 Magnetic Beads (VS-0724-YC888) is an innovative affinity resin which is bound with anti-DDB1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of DDB1 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45174/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68456/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32821/63256_A_8_8.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32821/63256_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32821/63256_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/32821/63256_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167986-DDB1
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-DDB1 specific antibody
- Target
- DDB1
- Immunogen
- Recombinant human DDB1 fragment derived from E. coli.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
- Alternative Names
- Damage Specific DNA Binding Protein 1; Xeroderma Pigmentosum Group E-Complementing Protein; UV-Damaged DNA-Binding Protein 1; UV-Damaged DNA-Binding Factor; DNA Damage-Binding Protein A; HBV X-Associated Protein 1; XPE-Binding Factor; DDB P127 Subunit; UV-DDB 1; XPE-BF; XAP-1;
- Gene ID
- 1642
- UniProt ID
- Q16531
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "DDB1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0948 | Hi-Affi™ Rabbit Anti-DDB1 Recombinant Antibody (clone DS948AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0464-CN | Rabbit Anti-DDB1 Recombinant Antibody (clone JU32-35) | WB, IF, IHC, IP | Rabbit IgG |
| MRO-1810-CN | Rabbit Anti-DDB1 Polyclonal Antibody (MRO-1810-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0474F | Mouse Anti-DDB1 Recombinant Antibody (ZG-0474F) | WB | Mouse IgG |
| VS3-FY446 | Recombinant Rabbit Anti-DDB1 Antibody (clone R07-2A3) | WB, IHC-F, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS4-WK139 | Mouse Anti-DDB1 Recombinant Antibody (VS4-WK139) | ELISA, WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY635 | Anti-DDB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1938 | Anti-Mouse DDB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1937 | Anti-Human DDB1 Immunohistochemistry Kit | IHC |
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