Rabbit Anti-DDR1 Polyclonal Antibody
CAT#: VS3-WK1567
This antibody is a rabbit polyclonal antibody against human DDR1, which has been shown to be significantly overexpressed in several human tumors. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human DDR1). It can detect endogenous levels of DDR1. This product was tested for use in WB and ELISA.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57194/if_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_9_8.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_5.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_A_5_6.jpg
Normal Tissue
Figure 6 Skin
Melanocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25656/57796_B_7_1.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HaCaT, HBEC3-KT, RT4, T-47d)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000204580-DDR1
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Specifications
- Immunogen
- Synthesized peptide derived from human DDR1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human DDR1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- Discoidin Domain Receptor Tyrosine Kinase 1; CD167 Antigen-Like Family Member A; Protein-Tyrosine Kinase RTK-6; Mammary Carcinoma Kinase 10; Tyrosine-Protein Kinase CAK; Cell Adhesion Kinase; Tyrosine Kinase DDR; EC 2.7.10.1; EDDR1; NTRK4; PTK3A; HGK2; RTK6; TRKE; CAK; NEP; Epithelial Discoidin Domain-Containing Receptor 1
- Gene ID
- 780
- UniProt ID
- Q08345
- Long Name
- Discoidin Domain Receptor Tyrosine Kinase 1
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Autophosphorylated in response to fibrillar collagen binding.
Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
- Protein Refseq
- NP_001189450.1
- Function
- Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "DDR1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-436 | Mouse Anti-DDR1 Recombinant Antibody (clone mAb 3E3) | ELISA, FC | Mouse IgG |
| MOB-1224CT | Recombinant Mouse anti-Human DDR1 Monoclonal antibody (3H5F23) | ELISA, IHC-P, WB | |
| HPAB-0061-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026) | ELISA | Mouse IgG |
| HPAB-0062-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039) | ELISA | Mouse IgG |
| VS-0723-WK89 | Human Anti-DDR1 Recombinant Antibody (VS-0723-WK89) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-433 | Mouse Anti-DDR1 Recombinant Antibody (clone 3E3); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0064-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0065-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2078); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0066-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2079); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0067-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2092); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-433 | Mouse Anti-DDR1 Recombinant Antibody (clone mAb 3E3); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0077-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05570); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0078-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05571); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0061-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0062-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-176MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab1) | IF | Human antibody |
| TAB-177MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab2) | IF | Human antibody |
| TAB-178MZ-S(P) | Anti-Human DDR1 Recombinant Antibody scFv Fragment (DDR1-ab3) | IF | Human antibody |
| TAB-176MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab1) | IF | Human antibody |
| TAB-177MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab2) | IF | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0953 | Hi-Affi™ Rabbit Anti-DDR1 Recombinant Antibody (clone DS953AB) | ELISA, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1235 | AbPlus™ Anti-DDR1 Magnetic Beads (VS-0724-YC1235) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY638 | Anti-DDR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC431 | Recombinant Anti-DDR1 Vesicular Antibody, EV Displayed (VS-0425-YC431) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC97 | SmartAb™ Recombinant Anti-DDR1 pH-dependent Antibody (Clone AB2004) | ELISA | Mouse IgG |
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