Mouse Anti-DNA Recombinant Antibody (clone BM9-7) (CAT#: FAMAB-0087CQ)

This product is a recombinant mouse antibody clone BM9-7, which specifically binds to DNA.


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Figure 1 Comparisons of dsDNA-binding activities between clonally related IgG2b anti-DNA mAb.

Figure 1 Comparisons of dsDNA-binding activities between clonally related IgG2b anti-DNA mAb.

dsDNA-binding activities were examined using synthetic dsDNA-coupled silica gel particles and flow cytometry. Each dsDNA-coupled particle was first stained with culture supernatant of mAb at given Ig concentrations and then stained with FITC-labeled anti-mouse Ig antibodies. dsDNA-binding activities were expressed by mean channels of fluorescence intensity.

Miyazaki, S., Shimura, J., Hirose, S., Sanokawa, R., Tsurui, H., Wakiya, M., ... & Shirai, T. (1997). Is structural flexibility of antigen-binding loops involved in the affinity maturation of anti-DNA antibodies?. International immunology, 9(5), 771-777.

Figure 2 Comparison of the flexibility of Fv loops during molecular dynamics, as determined by cluster graphs.

Figure 2 Comparison of the flexibility of Fv loops during molecular dynamics, as determined by cluster graphs.

Coordinates of all atoms were obtained at the time interval of 500 fs during the simulation period of 50 ps, each set of coordinates was saved as a frame and 100 frames were stored in chronological order. The extent of protein motions seen in the simulations was estimated by calculating the root mean square fluctuations of all atomic positions including side chains among 100 frames. Results are displayed in cluster graph, in which ranges of root mean square values of 0.00–1.00 Å are shown in the black area and those of .1.00 Å are in the white area.

Miyazaki, S., Shimura, J., Hirose, S., Sanokawa, R., Tsurui, H., Wakiya, M., ... & Shirai, T. (1997). Is structural flexibility of antigen-binding loops involved in the affinity maturation of anti-DNA antibodies?. International immunology, 9(5), 771-777.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG2b
  • Clone
  • BM9-7
  • Applications
  • ELISA
  • Related Disease
  • Systemic lupus erythematosus (SLE)

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Flow Cytometry.

Target

  • Alternative Names
  • DNA; Deoxyribonucleic acid; polynucleotides; double heliX

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone BM9-7"

See other products for "DNA"

Mouse Antibody

CAT Product Name Application Type
PABX-048 Recombinant Mouse Anti-DNA Antibody WB, ELISA, FuncS IgG
PABX-048-F (E) Recombinant Mouse Anti-DNA Antibody Fab Fragment WB, ELISA, FuncS Fab

Humanized Antibody

CAT Product Name Application Type
PABX-048-S (P) Recombinant Mouse Anti-DNA Antibody scFv Fragment WB, ELISA, FuncS scFv

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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