Rabbit Anti-DSC1 Recombinant Antibody (clone R93-2A-4) (CAT#: VS3-XY3337)
It is a recombinant rabbit antibody targeting the DSC1 (Desmocollin 1), which involves in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. It has been determined using Western Blot. The recommended dilutions of Western Blot is 1/500-1/1000.
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Normal Tissue
Figure 1 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_1_val_selected.jpg
Figure 2 Low expression in pancreas
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_3_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_3_3_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_B_8_5.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_8_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_6_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75379/165647_A_6_6.jpg
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat DSC1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R93-2A-4
- Applications
- WB
- Related Disease
- Subcorneal Pustular Dermatosis; Iga Pemphigus
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
Target
- Alternative Names
- CDHF1; DG2/DG3
- Gene ID
- 1823
- UniProt ID
- Q08554
- Long Name
- Desmocollin 1
- Cellular Localization
- Cell membrane, Cell junction, Desmosome
- Post Translation Modifications
- Glycosylation at Asn165 and Asn546 (NX_Q08554 [NX_Q08554-1])
Modification sites at PhosphoSitePlus (Q08554)
Glycosylation from GlyGen (Q08554) 9 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054174211.1; NP_004939.1
- Function
- Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "DSC1"
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IgG Antibody Products
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ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3293z | Mouse Anti-DSC1 Recombinant Antibody (clone 21D11) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| HPAB-0020-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0020-LSX) | ELISA | Human IgG |
| HPAB-0021-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0021-LSX) | ELISA | Human IgG |
| HPAB-0022-LSX | Human Anti-DSC1 Recombinant Antibody (HPAB-0022-LSX) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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