Recombinant Anti-DSG3 (EC1 domain x EC2 domain) Biparatopic Antibody, Tandem scFv (Clone PVA224 x Clone PVB28) (CAT#: VS-0525-YC50)

• Host Animal 1
• Human

• Host Animal 2
• Mouse

• Specificity
• EC1 domain of human desmoglein-3

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• PVA224

• Clone 2
• PVB28

• Epitope 1
• EC1 domain

• Epitope 2
• EC2 domain

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, IF, IHC

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Desmoglein 3

• Introduction
• This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.

• Alternative Names
• Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3

• Gene ID
• 1830

• UniProt ID
• P32926

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