Recombinant Anti-DSG3 (EC1 domain x EC2 domain) Biparatopic Antibody, Tandem scFv (Clone PVA224 x Clone PVB28)
CAT#: VS-0525-YC50
The recombinant Anti-DSG3 (EC1 domain x EC2 domain) biparatopic antibody, tandem scFv (Clone PVA224 x Clone PVB28), targets two distinct DSG3 sites. This antibody is formed as a tandem scFv, linking the PVA224 scFv targeted at the EC1 domain with the PVB28 scFv targeted at the EC2 domain.
Gene Expression
Normal Tissue
Figure 1 Esophagus
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HaCaT, hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
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Specifications
- Host Animal 1
- Human
- Host Animal 2
- Mouse
- Specificity
- EC1 domain of human desmoglein-3
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- PVA224
- Clone 2
- PVB28
- Epitope 1
- EC1 domain
- Epitope 2
- EC2 domain
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA, IF, IHC
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Desmoglein 3
Target
- Introduction
- This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3
- Gene ID
- 1830
- UniProt ID
- P32926
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
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| CAT | Product Name | Application | Type |
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| FAMAB-0515WJ | Human Anti-DSG3 Recombinant Antibody (clone PVE4-8) | ELISA, WB, IF | Human IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY74 | Human Anti-DSG3 (clone DF366) scFv-Fc Chimera | IHC, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC193 | Recombinant Anti-DSG3 Vesicular Antibody, EV Displayed (VS-0425-YC193) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY2095 | Anti-DSG3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2096 | Anti-Mouse DSG3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC52 | Recombinant Anti-DSG3 (EC3 domain x EC5 domain) Biparatopic Antibody, Tandem scFv (Clone PVA218 x Clone PVA232) | ELISA | Tandem scFv |
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