Recombinant Anti-DSG3 (EC3 domain x EC5 domain) Biparatopic Antibody, Tandem scFv (Clone PVA218 x Clone PVA232)
CAT#: VS-0525-YC52
The recombinant Anti-DSG3 (EC3 domain x EC5 domain) biparatopic antibody, tandem scFv (Clone PVA218 x Clone PVA232) is designed to target the EC3 and EC5 domains of DSG3. This antibody employs a tandem scFv arrangement, utilizing the PVA218 scFv with the PVA232 scFv.
Gene Expression
Normal Tissue
Figure 1 Esophagus
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HaCaT, hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
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Specifications
- Host Animal 1
- Mouse
- Host Animal 2
- Human
- Specificity
- EC3 domain of human desmoglein-3
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- PVA218
- Clone 2
- PVA232
- Epitope 1
- EC3 domain
- Epitope 2
- EC5 domain
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Desmoglein 3
Target
- Introduction
- This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris.
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3
- Gene ID
- 1830
- UniProt ID
- P32926
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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