Human Anti-DSG3 Recombinant Antibody (clone PVMAB786)
CAT#: FAMAB-0152JF
Recombinant monoclonal antibody specially binds to desmoglein 3 (Dsg3). This human anti-Dsg3 antibody PVMAB786 can e a useful reagent to study the mechanism of cell adhesion and detachment on tumor biology, specifically squamous cell carcinomas.
Gene Expression
Normal Tissue
Figure 1 Esophagus
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56863/148897_B_5_1.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HaCaT, hTCEpi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134757-DSG3
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Specifications
- Host Species
- Human
- Type
- Human IgG4
- Specificity
- Human Dsg3
- Species Reactivity
- Human
- Clone
- PVMAB786
- Applications
- WB, ELISA, IHC, FuncS
- Related Disease
- Pemphigus vulgaris
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The DSG3 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Functional Assay.
Target
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Specific To Extracellular Domain
We selected this antibody because it targets the extracellular domain I of Dsg3. It worked perfectly in our ELISA and Western blot assays, showing high specificity for the human protein. It is a valuable reagent for studying cell adhesion molecules.
Excellent For Adhesion Studies
This human recombinant antibody (clone PVMAB786) was highly effective in our functional assays related to cell adhesion. It also performed well in immunohistochemistry. The IgG4 isotype and high purity (>95%) make it a reliable choice for consistent experimental results.
Q&As
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What domain of Dsg3 does this antibody bind?
A: This recombinant monoclonal antibody (clone PVMAB786) binds specifically to the extracellular domain I of Desmoglein 3 (Dsg3). It is suitable for studying cell adhesion mechanisms in research settings.
-
What isotype is this antibody?
A: The isotype of this human recombinant antibody is IgG4. It is purified by affinity chromatography and is provided with high purity (>95%) for applications such as Western Blot, ELISA, IHC, and Functional Studies.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# FAMAB-0152JF, RRID: AB_3713724)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-172 | Human Anti-DSG3 Recombinant Antibody (clone PVA3) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-258MZ | Anti-Human DSG3 Recombinant Antibody (TAB-258MZ) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259MZ | Anti-Human DSG3 Recombinant Antibody (TAB-259MZ) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-260MZ | Anti-Human DSG3 Recombinant Antibody (TAB-260MZ) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-258MZ-S(P) | Anti-Human DSG3 Recombinant Antibody scFv Fragment (TAB-258MZ-S(P)) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259MZ-S(P) | Anti-Human DSG3 Recombinant Antibody scFv Fragment (TAB-259MZ-S(P)) | IHC, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2196MZ | Recombinant Mouse Anti-Human DSG3 Antibody (clone 4H244) | ICC, IF, IHC-P, IP, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1055 | Hi-Affi™ Rabbit Anti-DSG3 Recombinant Antibody (clone DS1055AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a) | ELISA, IF, IB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0205-CN | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9) | ELISA, IF, IB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); scFv Fragment | ELISA, IF, IB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0205-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0152JF-F(E) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); Fab Fragment | IF, WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0152JF-S(P) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); scFv Fragment | IF, WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1111CQ | Human Anti-DSG3 Recombinant Antibody (FAMAB-1111CQ) | IF, ELISA, IHC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY74 | Human Anti-DSG3 (clone DF366) scFv-Fc Chimera | IHC, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC193 | Recombinant Anti-DSG3 Vesicular Antibody, EV Displayed (VS-0425-YC193) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2095 | Anti-DSG3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2096 | Anti-Mouse DSG3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC50 | Recombinant Anti-DSG3 (EC1 domain x EC2 domain) Biparatopic Antibody, Tandem scFv (Clone PVA224 x Clone PVB28) | ELISA, IF, IHC | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC52 | Recombinant Anti-DSG3 (EC3 domain x EC5 domain) Biparatopic Antibody, Tandem scFv (Clone PVA218 x Clone PVA232) | ELISA | Tandem scFv |
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