Human Anti-DSG3 Recombinant Antibody (clone PVMAB786) (CAT#: FAMAB-0152JF)
Recombinant monoclonal antibody specially binds to desmoglein 3 (Dsg3). This human anti-Dsg3 antibody PVMAB786 can e a useful reagent to study the mechanism of cell adhesion and detachment on tumor biology, specifically squamous cell carcinomas.
Specific Inquiry
ELISA
Figure 1 Oral disease severity in pemphigus vulgaris (PV) and pemphigus foliaceus (PF) plotted against desmoglein (Dsg) 3 antibody levels measured by enzyme-linked immunosorbent assay (ELISA).
Median and quartile values are marked with red and green lines, respectively.
Harman, K. E., Seed, P. T., Gratian, M. J., Bhogal, B. S., Challacombe, S. J., & Black, M. M. (2001). The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. British Journal of Dermatology, 144(4), 775-780.
WB
Figure 2 Novel antigens recognized significantly differentially by pemphigus vulgaris (PV) antibodies.
The signal intensities of differentially reactive proteins associated with PV.
Kalantari‐Dehaghi, M., Molina, D. M., Farhadieh, M., John Morrow, W., Liang, X., Felgner, P. L., & Grando, S. A. (2011). New targets of pemphigus vulgaris antibodies identified by protein array technology. Experimental dermatology, 20(2), 154-156.
FuncS
Figure 3 The expression profiles for the keratoconus samples (gray) and the controls (white) normalized to GAPDH.
Sample numbers are shown at the bottom.
Nielsen, K., Heegaard, S., Vorum, H., Birkenkamp-Demtröder, K., Ehlers, N., & Orntoft, T. F. (2005). Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea, 24(6), 661-668.
IHC
Figure 4 Antibody staining against DSG3.
The granular localization of S100A2 is visible in a reference sample.
Nielsen, K., Heegaard, S., Vorum, H., Birkenkamp-Demtröder, K., Ehlers, N., & Orntoft, T. F. (2005). Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea, 24(6), 661-668.
Specifications
- Host Species
- Human
- Type
- Human IgG4
- Specificity
- Human Dsg3
- Species Reactivity
- Human
- Clone
- PVMAB786
- Applications
- WB, ELISA, IHC, FuncS
- Related Disease
- Pemphigus vulgaris
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The DSG3 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Functional Assay.
Target
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen
- Gene ID
- 1830
- UniProt ID
- P32926
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-258MZ | Anti-Human DSG3 Recombinant Antibody (DF151) | IHC, FC | |
| TAB-259MZ | Anti-Human DSG3 Recombinant Antibody (DF364) | IHC, FC | |
| TAB-260MZ | Anti-Human DSG3 Recombinant Antibody (DF366) | IHC, FC | |
| TAB-258MZ-S(P) | Anti-Human DSG3 Recombinant Antibody scFv Fragment (DF151) | IHC, FC | |
| TAB-259MZ-S(P) | Anti-Human DSG3 Recombinant Antibody scFv Fragment (DF364) | IHC, FC |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1055 | Hi-Affi™ Rabbit Anti-DSG3 Recombinant Antibody (clone DS1055AB) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0204-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3);3c/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0205-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0152JF-S(P) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); scFv Fragment | IF, WB, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0204-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3c/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0152JF-F(E) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); Fab Fragment | IF, WB, ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1111CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA224) | IF, ELISA, IHC | Human IgG1 |
| FAMAB-1113CQ | Mouse Anti-DSG3 Recombinant Antibody (clone PVB28) | IF, ELISA, IHC | Mouse IgG1 |
| FAMAB-1114CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA232) | ELISA | Human IgG1 |
| FAMAB-1115CQ | Human Anti-DSG3 Recombinant Antibody (clone PVB16) | IF, ELISA, IHC | Human IgG1 |
| FAMAB-1116CQ | Human Anti-DSG3 Recombinant Antibody (clone PVB124) | IF, ELISA, IHC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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