Anti-DUSP6 (clone W24V59) Recombinant Antibody Coupled Liposome (VS-1024-FY61)
CAT#: VS-1024-FY61
Antibody targeting DUSP6 combined with liposomes may represent a novel therapeutic strategy for breast cancer. DUSP6 is a dual-specificity phosphatase associated with the progression, recurrence, and metastasis of breast cancer. Therefore, targeting DUSP6 could counteract the negative effects of its overexpression in this cancer. The specific applications and effects need to be verified through further research.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53188/883_A9_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64692/1269_F9_1_selected.jpg
Normal Tissue
Figure 3 IHC staining of human bronchus
Immunohistochemical staining of human bronchus shows strong nuclear and cytoplasmic positivity in respiratory epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17566/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17566/40048_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17566/40048_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17566/40048_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17566/40048_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (AN3-CA, NB-4, SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139318-DUSP6
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V59
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a high specificity and binding affinity for human DUSP6, a dual-specificity phosphatase involved in various cellular signaling pathways. This unique binding characteristic of the antibody enables it to selectively recognize and interact with the DUSP6 protein, facilitating its potential use in a range of research and therapeutic applications.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- DUSP6
- Introduction
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
- Alternative Names
- Dual Specificity Phosphatase 6; Mitogen-Activated Protein Kinase Phosphatase 3; Dual Specificity Protein Phosphatase PYST1; MAP Kinase Phosphatase 3; PYST1; MKP3; Serine/Threonine Specific Protein Phosphatase
- Full Name
- Dual Specificity Phosphatase 6
- Gene ID
- 1848
- UniProt ID
- Q16828
- Sequence Similarities
- Belongs to the protein-tyrosine phosphatase family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( Q16828 )
Modification sites at neXtProt
- Protein Refseq
- NP_001937.2; NP_073143.2
- Function
- Inactivates MAP kinases.
Has a specificity for the ERK family (PubMed:9858808).
Plays an important role in alleviating chronic postoperative pain.
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Datasheet
MSDS
COA
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See other products for "DUSP6"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2096MZ | Recombinant Mouse Anti-Human DUSP6 Antibody | FC, ICC, IF, IHC-P, WB | Mouse antibody |
| MRO-0499-CN | Rabbit Anti-DUSP6 Recombinant Antibody (clone CBACN-203) | WB, IF, IHC, IP, FC | Rabbit IgG |
| VS3-XY595 | Mouse Anti-DUSP6 Recombinant Antibody (clone 3G1) | WB, IP, IF, IHC | Mouse IgG1 |
| VS3-WK1022 | Rabbit Anti-DUSP6 Recombinant Antibody (VS3-WK1022) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0177MZ | Chicken Anti-DUSP6 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1066 | Hi-Affi™ Rabbit Anti-DUSP6 Recombinant Antibody (clone DS1066AB) | IHC-P, WB, IP, FC, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY705 | Anti-DUSP6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2114 | Anti-Human DUSP6 Immunohistochemistry Kit | IHC |
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