Human Anti-EBOV GP Recombinant Antibody (clone 2.1.1D5) (CAT#: VS-0724-YC46)
2.1.1D5 was identified from peripheral blood mononuclear cell (PBMC) samples in a longitudinal analysis of EVD patients. 2.1.1D5 binds EBOV GP but not Sudan virus (SUDV) or Bundibugyo virus (BDBV) GP. 2.1.1D5 was thought to bind the GP1 core region (outside the mucinlike domain) based on a competition assay and escape mutation analysis, in which Y232H was identified as a key escape mutation. Furthermore, the mutations G118E, T144A, and G224D blocked 2.1.1D5 binding to GP expressed on the surface of Jurkat cells (Jurkat-GP4).
Specific Inquiry
Specifications
- Host Species
- Human
- Derivation
- Isolated from peripheral blood mononuclear cell (PBMC) samples in a longitudinal analysis of EVD patients.
- Type
- Human IgG
- Specificity
- EBOV glycoprotein (GP)
- Species Reactivity
- EBOV
- Clone
- 2.1.1D5
- Applications
- ELISA, Neut
Product Property
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- IC₅₀ = 1.55 nM in a pseudovirus neutralization assay using recombinant vesicμlar stomatitis virus (rVSV) expressing EBOV GP.
Target
- Alternative Names
- EBOV glycoprotein (GP); glycoprotein; GP
- Long Name
- Ebola virus (EBOV) surface glycoprotein (GP)
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-298-F(E) | Recombinant Anti-EBOV GP Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
| PFBW-038 | Recombinant Mouse Anti-EBOV GP Antibody Fab Fragment (14G7) | ELISA, Neut | IgG |
| PFBC-260 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c2G4) | ELISA, Neut | Human Fab |
| PFBC-261 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c13C6) | ELISA, Neut | Human Fab |
| PFBC-262 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (c4G7) | ELISA, Neut, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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