Rabbit Anti-Borrelia burgdorferi CRASP-1 Antibody (VS-0925-XY2)
CAT#: VS-0925-XY2
Antibodies against Borrelia burgdorferi CRASP-1 target this complement-evasion protein, enabling ELISA for detection, flow cytometry to analyze surface expression, and studies on its role in Lyme disease pathogen survival. Valuable for immune evasion research.
Specifications
- Host Animal
- Rabbit
- Applications
- WB, ELISA, IP
- Specificity
- Borrelia burgdorferi CRASP-1
- Target
- Borrelia burgdorferi CRASP-1
- Species Reactivity
- Bacteria
- Type
- Rabbit IgG
- Purification
- Protein A Purified
- Format
- Lyophilized
- Buffer
- Potassium phosphate, pH 7.2, with 0.15M NaCl
- Preservative
- 0.01% sodium azide
- Storage
- This item should be kept at 4°C if stored for a short period (1 to 2 weeks). For extended storage, maintain a temperature of -20°C. Repeated freeze-thaw cycles must be avoided.
Target
- Introduction
- Borrelia burgdorferi CRASP-1, short for Complement Regulator-Acquiring Surface Protein 1, is encoded by Borrelia burgdorferi, the main cause of Lyme disease. To survive in the host, this bacterium relies on CRASP-1 to evade the complement system. CRASP-1 specifically binds host complement regulators (e.g., factor H), using the host's own regulatory mechanism to inhibit complement activation and prevent complement complex formation on the bacterial surface, avoiding complement-mediated bacteriolysis. It is a key virulence factor for immune escape, providing a basis for understanding Lyme disease pathogenesis and a potential target for vaccine or immunotherapy development.
- Alternative Names
- B. burgdorferi Complement Regulator-Acquiring Surface Protein 1, Bb CRASP-1
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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