Rabbit Anti-Borrelia burgdorferi VlsE Antibody (VS-0925-XY8)
CAT#: VS-0925-XY8
Borrelia burgdorferi VlsE antibodies focus on this immune-evasion protein, supporting ELISA for chronic infection detection, Western blotting, and research on antigenic variation mechanisms in persistent Lyme disease.
Specifications
- Host Animal
- Rabbit
- Applications
- WB, ELISA, IP
- Specificity
- Borrelia burgdorferi VlsE
- Target
- Borrelia burgdorferi VlsE
- Species Reactivity
- Bacteria
- Type
- Rabbit IgG
- Purification
- Protein A Purified
- Format
- Lyophilized
- Buffer
- Potassium phosphate, pH 7.2, with 0.15M NaCl
- Preservative
- 0.01% sodium azide
- Storage
- This item should be kept at 4°C if stored for a short period (1 to 2 weeks). For extended storage, maintain a temperature of -20°C. Repeated freeze-thaw cycles must be avoided.
Target
- Introduction
- Borrelia burgdorferi VlsE, or Variable Major Protein-Like Sequence E, is the core molecule for bacterial antigen variation and long-term immune escape. Encoded by the vls gene family (with one expression site vlsE and multiple silent sites), the bacterium uses gene recombination to integrate silent site sequences into vlsE, causing high-frequency amino acid sequence variation in VlsE. When the host produces antibodies against the current VlsE, the bacterium generates a new subtype via variation, making the old antibodies ineffective, enabling chronic infection. Its variation mechanism is a research focus, and its conserved regions are used as specific markers for chronic Lyme disease diagnosis.
- Alternative Names
- B. burgdorferi Variable Major Protein-Like Sequence E, Bb VlsE
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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