Mouse Anti-Staphylococcus aureus PBP2a Antibody (VS-0925-XY62)
CAT#: VS-0925-XY62
Staphylococcus aureus PBP2a antibodies bind this penicillin-binding protein, enabling ELISA for MRSA detection, Western blotting to confirm resistance, and studies on its role in beta-lactam resistance. Key for MRSA diagnostic and drug development research.
Specifications
- Host Animal
- Mouse
- Applications
- ICC, IF
- Specificity
- Staphylococcus aureus PBP2a
- Target
- Staphylococcus aureus PBP2a
- Species Reactivity
- Bacteria
- Type
- Mouse IgG2a
- Purification
- Protein A Purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% sodium azide
- Storage
- This item should be kept at 4°C if stored for a short period (1 to 2 weeks). For extended storage, maintain a temperature of -20°C. Repeated freeze-thaw cycles must be avoided.
Target
- Introduction
- Staphylococcus aureus PBP2a (Penicillin-Binding Protein 2a) is a cell wall synthesis protein unique to methicillin-resistant Staphylococcus aureus (MRSA)-a major cause of drug-resistant bacterial infections worldwide. Unlike other penicillin-binding proteins (PBPs) in Staphylococcus aureus, PBP2a has a low affinity for beta-lactam antibiotics (e.g., methicillin, penicillin). Normally, beta-lactam drugs bind to PBPs and inhibit their role in cross-linking peptidoglycan (the main component of bacterial cell walls), leading to cell wall collapse and bacterial death. However, PBP2a remains active even in the presence of these drugs, allowing MRSA to continue synthesizing a functional cell wall and survive treatment. The gene encoding PBP2a (mecA) is carried on a mobile genetic element called the staphylococcal cassette chromosome mec (SCCmec). Due to its central role in MRSA's antibiotic resistance, PBP2a is a critical target for diagnostic tests (e.g., PCR detection of mecA or immunological detection of PBP2a) and the development of new anti-MRSA drugs that specifically inhibit its activity.
- Alternative Names
- S. aureus Penicillin-Binding Protein 2a, Sa PBP2a
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Staphylococcus aureus PBP2a"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0925-XY63 | Mouse Anti-Staphylococcus aureus PBP2a Antibody (VS-0925-XY63) | ICC, IF, ELISA | Mouse IgG2a |
| VS-0925-XY64 | Mouse Anti-Staphylococcus aureus PBP2a Antibody (VS-0925-XY64) | WB, ICC, IF, ELISA | Mouse IgG2a |
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