Mouse Anti-Streptococcus pneumoniae CPS Antibody (VS-0925-XY67)
CAT#: VS-0925-XY67
Streptococcus pneumoniae CPS antibodies bind this capsular polysaccharide, supporting ELISA for serotype detection, immunofluorescence in lung tissues, and studies on its role in phagocytosis resistance. Critical for pneumococcal vaccine research and pneumonia diagnostic studies.
Specifications
- Host Animal
- Mouse
- Applications
- ICC, IF, ELISA
- Specificity
- Streptococcus pneumoniae CPS
- Target
- Streptococcus pneumoniae CPS
- Immunogen
- Proprietary sequence
- Species Reactivity
- Bacteria
- Type
- Mouse IgG1
- Purification
- Protein A Purified
- Format
- Liquid
- Buffer
- PBS, pH 7.2
- Preservative
- 0.1% sodium azide
- Storage
- This item should be kept at 4°C if stored for a short period (1 to 2 weeks). For extended storage, maintain a temperature of -20°C. Repeated freeze-thaw cycles must be avoided.
Target
- Introduction
- Streptococcus pneumoniae CPS (Capsular Polysaccharide) is a complex carbohydrate layer surrounding the cell wall of Streptococcus pneumoniae, a major cause of pneumonia, meningitis, and otitis media. The CPS is a key virulence factor: it protects the bacterium from phagocytosis by host immune cells (e.g., macrophages) by masking bacterial surface antigens that would otherwise trigger immune recognition. This protection allows Streptococcus pneumoniae to colonize the upper respiratory tract and spread to other tissues (e.g., lungs, brain). There are over 90 distinct serotypes of Streptococcus pneumoniae, each defined by unique CPS structures. The CPS is also highly immunogenic, and antibodies against a specific CPS serotype provide protective immunity against that serotype. This property forms the basis of pneumococcal vaccines, which contain purified CPS from the most common pathogenic serotypes. Vaccination induces the production of anti-CPS antibodies, enabling the immune system to recognize and clear Streptococcus pneumoniae before infection progresses. The CPS also serves as a target for diagnostic tests (e.g., latex agglutination assays) to identify Streptococcus pneumoniae serotypes in clinical samples.
- Alternative Names
- S. pneumoniae Capsular Polysaccharide, Sp CPS
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Downloadable Resources
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Datasheet
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COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Recommended Dilution Buffer
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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