Anti-ENG (clone 6B10) Recombinant Antibody Coupled Liposome (VS-1024-FY79)
CAT#: VS-1024-FY79
Liposomes conjugated with anti-APRIL antibodies represent a promising strategy in the treatment of gliomas, a type of aggressive brain tumor. By attaching specific antibodies to liposomes, researchers aim to facilitate targeted delivery of therapeutic agents directly to tumor cells, thereby minimizing damage to healthy surrounding tissue. This targeted approach not only improves the localization of the drug but also enhances its overall therapeutic efficacy, potentially leading to better clinical outcomes for patients. Moreover, the use of antibody-conjugated liposomes may help to overcome common treatment challenges, such as drug resistance and limited penetration into the tumor microenvironment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1823_F9_38_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11862/158146_A_2_7_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1777_G1_13_cr59632eeaa8e82_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nuclear bodies & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/1759_C2_13_cr594b6f97edc10_blue_red_green.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/67440/156475_A_9_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (fHDF/TERT166, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000106991-ENG
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- 6B10
- Antibody Type
- IgG1, kappa
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a chimeric (human/mouse) monoclonal antibody that was designed to target the human protein ENG (CD105). By binding to CD105, which plays a crucial role in tumor angiogenesis, this antibody has the potential to exhibit anti-angiogenic and anti-tumor properties.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- ENG
- Introduction
- This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1
- Full Name
- Endoglin
- Gene ID
- 2022
- UniProt ID
- P17813
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
Required for normal structure and integrity of adult vasculature (PubMed:7894484).
Regulates the migration of vascular endothelial cells (PubMed:17540773).
Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
- Protein Refseq
- NP_000109.1; NP_001108225.1; NP_001265067.1
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 6B10"
- CAT
- Product Name
See other products for "ENG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1309z | Mouse Anti-ENG Recombinant Antibody (clone 27H2) | IF, IHC, WB | Mouse IgG1 |
| FN-061CQ | Mouse Anti-ENG Recombinant Antibody (clone SN6) | FC, FuncS, IHC | Mouse IgG1, κ |
| HPAB-0448-FY | Rat Anti-ENG Recombinant Antibody (HPAB-0448-FY) | ELISA, Inhib, FuncS | Rat IgG1 |
| ZG-0076J | Mouse Anti-ENG Recombinant Antibody (ZG-0076J) | IHC-P, IF | Mouse IgG |
| ZG-0077J | Mouse Anti-ENG Recombinant Antibody (ZG-0077J) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1569CL | Human Anti-ENG Recombinant Antibody (TAB-1569CL) | ELISA, FC | Human antibody |
| TAB-1571CL | Human Anti-ENG Recombinant Antibody (TAB-1571CL) | ELISA, FC | Human IgG1 |
| TAB-1577CL | Anti-Human ENG Recombinant Antibody (9H10) | FuncS | Fully human antibody |
| TAB-1569CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1569CL-S(P)) | ELISA, FC | Human scFv |
| TAB-1571CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1571CL-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1573CL | Mouse Anti-ENG Recombinant Antibody (TAB-1573CL) | FC, Apop | Mouse IgG |
| TAB-1573CL-S(P) | Mouse Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1573CL-S(P)) | FC, Apop | Mouse scFv |
| TAB-1574CL-S(P) | Mouse Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1574CL-S(P)) | FC | Mouse scFv |
| TAB-1573CL-F(E) | Mouse Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1573CL-F(E)) | FC, Apop | Mouse Fab |
| TAB-1574CL-F(E) | Mouse Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1574CL-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1575CL | Human Anti-ENG Recombinant Antibody (TAB-1575CL) | Apop | Humanized antibody |
| TAB-1576CL | Human Anti-ENG Recombinant Antibody (TAB-1576CL) | Cyt, ELISA, FC, FuncS | Humanized antibody |
| TAB-1575CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1575CL-S(P)) | Apop | Human scFv |
| TAB-1576CL-S(P) | Human Anti-ENG Recombinant Antibody; scFv Fragment (TAB-1576CL-S(P)) | Cyt, ELISA, FC, FuncS | Human scFv |
| TAB-1575CL-F(E) | Human Anti-ENG Recombinant Antibody; Fab Fragment (TAB-1575CL-F(E)) | Apop | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0189MZ | Chicken Anti-Endoglin Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-726CQ | Mouse Anti-ENG Recombinant Antibody (clone 7D11) | WB, Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1150 | Hi-Affi™ Rabbit Anti-ENG Recombinant Antibody (clone DS1150AB) | WB, IHC-P, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-013ML | Anti-Human ENG Recombinant Antibody (TAB-013ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0231-YC-F(E) | Human Anti-ENG Recombinant Antibody (clone Vκ2VH1); Fab Fragment | ELISA, WB, FuncS | Humanized Fab |
| HPAB-0713-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 6B10); Fab Fragment | WB, FC | Human Fab |
| HPAB-0714-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 4.120); Fab Fragment | WB, FC | Human Fab |
| HPAB-0715-CN-F(E) | Human Anti-ENG Recombinant Antibody (clone 4.37); Fab Fragment | WB, FC | Human Fab |
| HPAB-AP642-YC-F(E) | Human Anti-ENG Recombinant Antibody (clone Vκ1VH1); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0713-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 6B10); scFv Fragment | WB, FC | Human scFv |
| HPAB-0714-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 4.120); scFv Fragment | WB, FC | Human scFv |
| HPAB-0715-CN-S(P) | Human Anti-ENG Recombinant Antibody (clone 4.37); scFv Fragment | WB, FC | Human scFv |
| HPAB-AP642-YC-S(P) | Human Anti-ENG Recombinant Antibody (clone Vκ1VH1); scFv Fragment | ELISA | Humanized scFv |
| HPAB-AP644-YC-S(P) | Human Anti-ENG Recombinant Antibody (clone Vκ2VH2); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-013ML | Afuco™ Anti-ENG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-013ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0613 | PE-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0614 | APC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0615 | FITC-A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC | |
| MHC-CN0616 | A*02:01/Human ENG (LLTAALWYV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0707-YJ-VHH | Camelid Anti-ENG Recombinant Single Domain Antibody (HPAB-0707-YJ-VHH) | ELISA, ICC | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1247 | AbPlus™ Anti-ENG Magnetic Beads (VS-0724-YC1247) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY186 | Mouse Anti-NHP ENG Recombinant Antibody (clone ENG/1621) | IF, FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY103 | CytoStream™ Mouse Anti-ENG Recombinant Antibody (VS-0225-XY103) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY146 | Human Anti-ENG (clone 6B10) scFv-Fc Chimera | WB, FC, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC237 | Recombinant Anti-ENG Vesicular Antibody, EV Displayed (VS-0425-YC237) | Cyt, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2282 | Anti-Mouse ENG Immunohistochemistry Kit | IHC |
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