Anti-EPAS1 (clone W24V177) Recombinant Antibody Coupled Liposome (VS-1024-FY178)
CAT#: VS-1024-FY178
The anti-EPAS1 antibody conjugated liposome demonstrates targeted action against the hypoxic microenvironment in melanoma, as EPAS1 is associated with tumor cell survival and proliferation. The aim of using this liposome is to block EPAS1 signaling pathways, thereby inhibiting tumor growth. Research indicates that this strategy has the potential to improve treatment efficiency and reduce side effect.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31200/1391_B7_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69697/1382_A10_1_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (BEWO, BJ hTERT+, HHSteC, RT4, TIME, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116016-EPAS1
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V177
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was specifically designed to target the EPAS1 protein. EPAS1, also known as HIF-2α, is a critical transcription factor involved in the regulation of genes related to oxygen homeostasis, cellular responses to hypoxia, and various cellular processes including angiogenesis and erythropoiesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- EPAS1
- Introduction
- This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
- Alternative Names
- Endothelial PAS Domain Protein 1; Class E Basic Helix-Loop-Helix Protein 73; Basic-Helix-Loop-Helix-PAS Protein MOP2; PAS Domain-Containing Protein 2; Member Of PAS Protein 2; HIF-1-Alpha-Like Factor; HIF-2-Alpha; HIF2-Alpha; BHLHe73; EPAS-1; HIF2A
- Full Name
- Endothelial PAS Domain Protein 1
- Gene ID
- 2034
- UniProt ID
- Q99814
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated on multiple sites in the CTAD. ( Q99814-EPAS1_HUMAN )
The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains. ( Q99814-EPAS1_HUMAN )
Modification sites at PhosphoSitePlus ( Q99814 )
Modification sites at neXtProt ( NX_Q99814 )
Glycosylation from GlyGen (Q99814) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011531000.1; XP_054196990.1; NP_001421.2
- Function
- Transcription factor involved in the induction of oxygen regulated genes.
Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity).
Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung.
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Datasheet
MSDS
COA
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See other products for "EPAS1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4055z | Mouse Anti-EPAS1 Recombinant Antibody (clone 13F1) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-0918CT | Recombinant Mouse anti-Human EPAS1 Monoclonal antibody (fq200c) | ELISA, IHC-Fr, IHC-P, WB | |
| MRO-0737-CN | Rabbit Anti-EPAS1 Recombinant Antibody (clone JB24-42) | WB, IHC, FC | Rabbit IgG |
| ZG-0651J | Rabbit Anti-EPAS1 Recombinant Antibody (clone 6A9) | ELISA, IF | Rabbit IgG |
| VS7-0425-WR35 | Mouse Anti-EPAS1 Recombinant Antibody (clone 1H3E12) | IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1161 | Hi-Affi™ Rabbit Anti-EPAS1 Recombinant Antibody (clone DS1161AB) | WB, FC, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC359 | CytoStream™ Rabbit Anti-EPAS1 Recombinant Antibody (VS13-YC359) | WB, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2303 | Anti-EPAS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2304 | Anti-Mouse EPAS1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2305 | Anti-Bovine EPAS1 Immunohistochemistry Kit | IHC |
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