Anti-EPHA5 Antibody Prodrug, Protease Activated (11C12)
CAT#: VS-1025-YC86
The Anti-EPHA5 Antibody Prodrug, Protease Activated (11C12) is an antibody prodrug comprised of a recombinant mouse antibody targeting human EPHA5, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to EPHA5 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to EPHA5 effectively. EPHA5 (Ephrin Receptor A5) is a receptor tyrosine kinase that is primarily noted for its expression in the nervous system, but it often acts as a tumor suppressor in certain cancers, particularly neuroblastoma. Its signaling, typically initiated by cell-to-cell contact with its ligand (ephrin A5), often induces cell repulsion, which can inhibit the invasion and migration of malignant cells.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (hTERT-RPE1, PC-3, TIME, U-138 MG, U-2197, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145242-EPHA5
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Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human EPHA5
- Target
- EPHA5
- Species Reactivity
- Human
- Isotype
- IgG1
- Clone
- 11C12
- Epitope
- AA 304-467
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described.
- Alternative Names
- EPHA5; EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4
- Gene ID
- 2044
- UniProt ID
- P54756
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 11C12"
- CAT
- Product Name
See other products for "EPHA5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0653CT | Recombinant Mouse anti-Human EPHA5 Monoclonal antibody (9C20C2,9C20G6) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-WJ | Mouse Anti-EPHA5 Recombinant Antibody (clone 11C12) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-WJ-S(P) | Mouse Anti-EPHA5 Recombinant Antibody (clone 11C12); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0010-WJ-F(E) | Mouse Anti-EPHA5 Recombinant Antibody (clone 11C12); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0296J | Mouse Anti-EPHA5 Recombinant Antibody (ZG-0296J) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX372 | Mouse Anti-EPHA5 Recombinant Antibody (clone 46CT61.6.4) | WB, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY178 | Human Anti-EphA5 (clone 11C12) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-HM873 | Mouse Anti-EPHA5 Recombinant Antibody (clone CBL236HM) | WB, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC679 | Recombinant Anti-EPHA5 Vesicular Antibody, EV Displayed (VS-0425-YC679) | ELISA, FC, Cell-uptake |
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