Human Anti-ERBB2 Recombinant Antibody (clone 1.D2) (CAT#: HPAB-1334WJ)
This product is a human antibody which specifically binds to HER2/neu. This antibody can be used for the diagnosis and treatment of HER2/neu-related disease.
Specific Inquiry
FC
Figure 1 Flow cytometry analysis of Her2-PE antibody.
Her2-S-Fab recognizes Her2 positive cells.
Li, A., Xing, J., Li, L., Zhou, C., Dong, B., He, P., ... & Wang, Z. (2016). A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells. AMB Express , 6 (1), 32.
FuncS
Figure 2 Dose dependent cytotoxicity assays were performed as described in CHO cell line.
Her2-S-Fab induces NK cell-mediated cytotoxicity.
Li, A., Xing, J., Li, L., Zhou, C., Dong, B., He, P., ... & Wang, Z. (2016). A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells. AMB Express , 6 (1), 32.
Inhib
Figure 3 Her2-S-Fab inhibits tumor growth in vivo.
Error bars represent the standard deviation.
Li, A., Xing, J., Li, L., Zhou, C., Dong, B., He, P., ... & Wang, Z. (2016). A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells. AMB Express , 6 (1), 32.
Specifications
- Immunogen
- Purified or enriched preparation of HER2/neu antigen
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human HER2/neu
- Species Reactivity
- Human
- Clone
- 1.D2
- Applications
- Inhib, FuncS, FC, ELISA
- Related Disease
- HER2/neu-related disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HER2/neu antibody has been reported in applications of Functional Assay, Enzyme-linked Immunosorbent Assay, Flow Cytometry, Inhibition.
Target
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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