Human Anti-ERBB2 Recombinant Antibody (clone C6L1) (CAT#: FAMAB-0171JF)
Recombinant monoclonal antibody specially binds to human tumor antigen ERBB2. This human anti-ERBB2 antibody (C6L1) can be useful in therapy of cancers.
Specific Inquiry
WB
Figure 1 Time course of tyrosine phosphorylation of erbB2 in wounded THCE cells.
The agarose-conjugated pY20 (phosphotyrosine-specific) antibodies, subjected to SDS-PAGE, and immunoblotted with anti-erbB2 antibody.
Xu, K. P., Riggs, A., Ding, Y., & Fu-Shin, X. Y. (2004). Role of ErbB2 in corneal epithelial wound healing. Investigative ophthalmology & visual science, 45(12), 4277-4283.
IHC
Figure 2 Effects of 5R expression on healing of scratch wounds.
Functional depletion of erbB2 in THCE cells delayed healing of scratch wounds.
Xu, K. P., Riggs, A., Ding, Y., & Fu-Shin, X. Y. (2004). Role of ErbB2 in corneal epithelial wound healing. Investigative ophthalmology & visual science, 45(12), 4277-4283.
ELISA
Figure 3 ELISA assays of SKBR3 cells (black symbols) and A431 cells (empty symbols) tested with Erb-hcAb (circles), the parental anti-ErbB2 scFv (rhomboids), or Herceptin (squares).
Effects of Erb-hcAb on ErbB2-positive (SKBR3) and ErbB2-negative (A431) cells.
De Lorenzo, C., Tedesco, A., Terrazzano, G., Cozzolino, R., Laccetti, P., Piccoli, R., & D'Alessio, G. (2004). A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent. British journal of cancer, 91(6), 1200-1204.
Specifications
- Host Species
- Human
- Derivation
- Human phage display scFv library
- Type
- Human IgG
- Specificity
- Human ERBB2
- Species Reactivity
- Human
- Clone
- C6L1
- Applications
- WB, ELISA, IHC
- Related Disease
- Tumors
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The ERBB2 antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-059 | Recombinant Anti-Human ERBB2 VHH Single Domain Antibody | IHC, FC, CA, FuncS | Llama VHH |
| TAB-032CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody | WB | Single domain antibody |
| TAB-046CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody (TAB-046CT) | ELISA, Inhibition, FC | Single domain antibody |
| TAB-047CT | Anti-Human HER2/neu Therapeutic Single Domain Antibody (TAB-047CT) | WB | Single domain antibody |
| HPAB-0725-YJ-VHH | Camelid Anti-ERBB2 Recombinant Single Domain Antibody (HPAB-0725-YJ-VHH) | ELISA | Camelid VHH |
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| IAB-B008(T) | Recombinant Anti-human ERBB2 Intrabody [Tat] | ICC, Neut, FuncS | scFv-Tat |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-005 | Anti-Human ErbB2 Recombinant Antibody (Trastuzumab) | FC, IP, ELISA, Neut, FuncS, IF, IHC | IgG1 - kappa |
| TAB-H70 | Anti-Human ERBB2 Recombinant Antibody (Trastuzumab Emtansine) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
| TAB-053 | Anti-Human ERBB2 Recombinant Antibody (Pertuzumab) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG1 - kappa |
| TAB-050CT | Anti-Human HER2/neu Recombinant Antibody (HuA21) | Inhib, Cty, IHC, WB, IF, FC, ELISA | Humanized antibody |
| TAB-041CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-041CT-S(P)) | ELISA, WB | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-761 | Anti-ERBB2 Recombinant Antibody (Margetuximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
| TAB-049CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
| TAB-049CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G022E | Anti-ERBB2 immunotoxin 4D5 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G022S | Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap | Cytotoxicity assay, Function study |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-085 | Human Anti-ERBB2 Recombinant Antibody (PABL-085) | ELISA, WB, FuncS | Human IgG |
| MOB-014LC | Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC) | ELISA, FC | Mouse IgG |
| MOB-014LC-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (MOB-014LC-F(E)) | ELISA, FC | Mouse Fab |
| MOB-014LC-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (MOB-014LC-S(P)) | ELISA, FC | Mouse scFv |
| FAMAB-0098YC | Mouse Anti-ERBB2 Recombinant Antibody (clone E402) | Cyt | Mouse IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-157 | Human Anti-ERBB2 Recombinant Antibody (clone F0178C1); scFv Fragment | Neut | Human scFv |
| PSBC-158 | Human Anti-ERBB2 Recombinant Antibody (clone Pertuzumab, 2C4); scFv Fragment | IP, Neut | Human scFv |
| HPAB-0010-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0010-FY-F(E)) | ELISA, FC | Human Fab |
| HPAB-0011-FY-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0011-FY-F(E)) | Inhib | Mouse Fab |
| HPAB-0608LY-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-0608LY-F(E)) | ELISA, Inhib | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-036CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (6B2) | ELISA, WB | |
| TAB-270CQ | Mouse Anti-ERBB2 Recombinant Antibody (TAB-270CQ) | WB, Inhib | Mouse IgG |
| TAB-270CQ-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-270CQ-S(P)) | WB, Inhib | Mouse scFv |
| TAB-270CQ-F(E) | Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-270CQ-F(E)) | WB, Inhib | Mouse Fab |
| PABX-082-S (P) | Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6) | WB, ELISA, FuncS | scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-040CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5) | FC, IP, Block | Human antibody |
| TAB-055CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment | WB | Human antibody |
| TAB-056CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-056CT-S(P)) | WB | Human scFv |
| TAB-042CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (CRX01) | WB | Human antibody |
| TAB-043CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-043CT-F(E)) | ELISA, Inhibion | Human Fab |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| Gly-039LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-118LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Mouse antibody |
| Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-148LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| BRD-0695MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| BRD-0779MZ | Chicken Anti-ErbB2 Polyclonal IgY | ICC, IF, IHC, IP | Chicken antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
| MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
| MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4486 | PE-Mamu-B*017:04/Human ERBB2 (SPAFDNLYYW) MHC Tetramer | FCM | |
| MHC-YF221 | A*02:01/Human Her-2/neu (KIFGSLAFL) MHC Monomer | MHC Multimer | |
| MHC-YF222 | A*02:01/Human Her-2/neu (RLLQETELV) MHC Monomer | MHC Multimer | |
| MHC-YF475 | A*02:01/Human HER2 (ILHDGAYSL) MHC Pentamer | FCM | |
| MHC-YF476 | A*02:01/Human HER2 (ALIHHNTHL) MHC Pentamer | FCM |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Timigutuzumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Pertuzumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Margetuximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody (Trastuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1333WJ-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone 3.F2); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-1334WJ-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone 1.D2); scFv Fragment | ELISA, WB | Human scFv |
| HPAB-S0027-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone F5); scFv Fragment | ELISA, Inhib, Internalization | Human scFv |
| HPAB-S0028-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody (clone C1); scFv Fragment | ELISA, Inhib, Internalization | Human scFv |
| HPAB-1855-FY-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-1855-FY-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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