Provided is a monoclonal antibody combing and inhibiting activation of epidermal growth factor relevant members Erbb3/Her3. The KD value of 09D03 to ERBB3 is 55 pM. The antibody can be used for the esophagus cancer research.
Figure 1A-1B are graphs summarizing results from an experiment to measure the neutralization activity of negative control (murine IgG (Δ)) and anti-ErbB3 monoclonal antibodies 04D01 (▪), 12A07 (◯), 18H02 (▯), 22A02 (□) and 24C05 (Q) to inhibit NRG1-β1 binding to hErbB3 (Figure 1A) and to measure the enhanced binding of NRG1-β1 to rhErbB3 by the anti-ErbB3 mAb 09D03 (▴) and 11G01 (*) (Figure 1B).
Figure 2 is a graph summarizing results from an experiment to measure the neutralization activity of negative control (murine IgG) and anti-ErbB3 monoclonal antibodies 04D01, 09D03, 11G01, 12A07, 18H02, 22A02 and 24C05 to inhibit NRG1-al binding to rhErbB3.
Figure 3 is a graph summarizing results from an experiment to measure the cell surface recognition of the anti-ErbB3 antibodies of the chimeric protein Her2/3d2 expressed at the surface of CHO cells.
Figure 4 is a graph summarizing results from an experiment to measure the anti-proliferation activity of negative control IgG (murine IgG (Δ)) and anti-ErbB3 monoclonal antibodies 04D01 (▪), 09D03 (▾), 11G01 (♦), 12A07 (◯), 18H02 (⋄), 22A02 (▯) and 24C05 (□) in BaF/3 cells expressing Her2 and ErbB3 in presence of NRG1-β1.
Figure 5 is a graph summarizing results from an experiment to measure the anti-proliferation activity of anti-ErbB3 monoclonal antibodies 04D01 (▪), 09D03 (▾), 11G01 (♦), 12A07 (▪), 18H02 (⋄), 22A02 (▯) and 24C05 (□) in MCF7 cells in the presence of NRG1-β1.
Figure 6 is a graph summarizing results from an experiment to measure the anti-proliferation activity of negative control (murine IgG) and anti-ErbB3 monoclonal antibodies 04D01, 09D03, 11G01, 12A07, 18H02, 22A02 and 24C05 in SKBR-3 cells treated with 5 μg/ml of antibodies in the presence of serum.
Figure 7 is graph summarizing results from an experiment to measure the inhibitory activity of negative control IgG and anti-ErbB3 monoclonal antibodies 04D01, 09D03, 11G01, 12A07, 18H02, 22A02 and 24C05 on the phosphorylation of ErbB3 induced by NRG in SKBR-3 cells.
Figure 8 is a graph summarizing results from an experiment to measure the tumor inhibitory activity of the anti-ErbB3 antibodies 04D01 (Δ), 09D03 (*), 11G01 (□), 12A07 (▴), 18H02 (▯), 22A02 (▪), 24C05 (◯) and a human IgG control (- -▪- -) dosed at 20 mg/kg in a BxPC3 pancreatic tumor xenograft model in CB 17 SCID mice (vehicle control, PBS (♦)).
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1729-sdAb | Recombinant Anti-human ERBB3 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
TAB-070CT | Llama Anti-ERBB3 Recombinant Single Domain Antibody (TAB-070CT) | FC, Block | Llama VHH |
PABC-556 | Recombinant Llama Anti-ERBB3 Single Domain Antibody (BCD090-M2) | ELISA, SPR | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-892 | Anti-Human ERBB3/ErbB 3 Recombinant Antibody (Seribantumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG2 - lambda |
TAB-057CT | Human Anti-ERBB3 Recombinant Antibody (TAB-057CT) | Inhibion, ELISA | Humanized antibody |
TAB-058CT | Human Anti-ERBB3 Recombinant Antibody (TAB-058CT) | ELISA, Inhib, Cty, IHC, WB, FC | Human IgG1, κ |
TAB-057CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-057CT-F(E)) | Inhibion, ELISA | Humanized Fab |
TAB-058CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-058CT-F(E)) | WB, ELISA, Inhib | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L074E | HRGβ2-PE immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379) | ELISA, WB, IF, FuncS | Human IgG |
PABL-127 | Human Anti-ERBB3 Recombinant Antibody (PABL-127) | ELISA, WB, FuncS | Human IgG |
PABL-128 | Mouse Anti-ERBB3 Recombinant Antibody (PABL-128) | WB, Block, FuncS | Mouse IgG |
HPAB-0286-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153) | ELISA, FuncS, FC | Mouse IgG |
HPAB-0287-YC | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104) | ELISA, FuncS, FC | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-086 | Human Anti-ERBB3 Recombinant Antibody (clone KTN3379); Fab Fragment | ELISA, WB, IF, FuncS | Human Fab |
HPAB-0286-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1153); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
HPAB-0287-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 920104); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
HPAB-0288-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1126); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
HPAB-0289-YC-F(E) | Mouse Anti-ERBB3 Recombinant Antibody (clone 12511); Fab Fragment | ELISA, FuncS, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-061CT | Human Anti-ERBB3 Recombinant Antibody (TAB-061CT) | Inhib, ELISA | Chimeric (Rabbit/Human) antibody |
TAB-061CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P)) | Inhib, ELISA | Human scFv |
TAB-061CT-F(E) | Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E)) | Inhib, ELISA | Chimeric (Rabbit/Human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-065CT | Human Anti-ERBB3 Recombinant Antibody (TAB-065CT) | ELISA, FC | Human IgG1 |
TAB-062CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-062CT-S(P)) | ELISA, Inhib, FC | Human scFv |
TAB-065CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-065CT-S(P)) | ELISA, FC | Human scFv |
TAB-066CT-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-066CT-S(P)) | ELISA, Inhibion, FC | Human scFv |
TAB-422CQ | Anti-Human ERBB3 Recombinant Antibody (Elgemtumab) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-064CT-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-064CT-F(E)) | ELISA, FC | Mouse Fab |
TAB-067CT-F(E) | Anti-Human HER3 Recombinant Antibody Fab Fragment (5101) | ELISA, Inhibition, FC | |
TAB-068CT-F(E) | Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-068CT-F(E)) | ELISA, Inhib, FC, WB | Mouse Fab |
TAB-069CT-F(E) | Anti-Human HER3 Recombinant Antibody Fab Fragment (muHER3-8 ) | ELISA, Inhibition, FC | |
TAB-071CT-F(E) | Anti-Human HER3 Recombinant Antibody Fab Fragment (SGP1) | IF, Inhibition, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-738CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932) | Neut, IP | Mouse IgG1 |
NEUT-739CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone CBL483) | FC, CyTOF®, ELISA, Neut | Mouse IgG1 |
NEUT-740CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1019) | Neut | Human IgG1, κ |
NEUT-741CQ | Human Anti-ERBB3 Recombinant Antibody (clone CBL1020) | Neut | Human IgG1, κ |
NEUT-742CQ | Mouse Anti-ERBB3 Recombinant Antibody (clone M908) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1179 | Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB) | ICC, IF, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H21 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-422CQ | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Elgemtumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
AFC-TAB-189 | Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | Human IgG1, κ |
AFC-TAB-H22 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Duligotuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
AFC-TAB-892 | Afuco™ Anti-ERBB3 ADCC Recombinant Antibody (Seribantumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0275-YJ-S(P) | Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0275-YJ-S(P)) | ELISA, FC, IHC, Inhib, IP, WB, FuncS | Mouse scFv |
HPAB-0276-YJ-S(P) | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0276-YJ-S(P)) | ELISA, FC, IHC, Inhib, IP, WB, FuncS | Humanized scFv |
HPAB-0436-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 15D5); scFv Fragment | Inhib | Mouse scFv |
HPAB-0437-FY-S(P) | Mouse Anti-ERBB3 Recombinant Antibody (clone 1D9); scFv Fragment | Inhib | Humanized scFv |
PSBS-0069 | Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (PSBS-0069) | ELISA, Block, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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