AbPlus™ Anti-ERBB3 Magnetic Beads (VS-0724-YC1400)

Name: AbPlus™ Anti-ERBB3 Magnetic Beads (VS-0724-YC1400)
SKU: VS-0724-YC1400
Rating: 5 (1 reviews)

CAT#: VS-0724-YC1400

The AbPlus Anti-ERBB3 Magnetic Beads (VS-0724-YC1400) is an innovative affinity resin which is bound with anti-ERBB3 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of ERBB3 protein under native and denaturing conditions.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70524/162441_A_4_2_selected.jpg

Subcellular Location and Protein Expression Figure 4 IHC staining of human kidney

Immunohistochemical staining of human kidney shows strong cytoplasmic and membranous positivity in renal tubular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_8_5_selected.jpg

Subcellular Location and Protein Expression Figure 5 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/659_B11_4_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 6 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/658_B11_1_blue_red_green.jpg

Normal Tissue Figure 7 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_7_5.jpg

Normal Tissue Figure 8 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25331/67596_A_9_3.jpg

Normal Tissue Figure 9 Liver

Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_8_4.jpg

Normal Tissue Figure 10 Kidney

Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_5.jpg

Normal Tissue Figure 11 Testis

Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_4_6.jpg

Normal Tissue Figure 12 Skin

Fibroblasts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Keratinocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Langerhans
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Melanocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/115200_B_8_1.jpg

Normal Tissue Figure 13 Lymph node

Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/45396/114856_A_9_8.jpg

RNA Expression Figure 14 RNA cell line category: Cell line enhanced (Hep G2, OE19, RT4, SK-BR-3, SK-MEL-30, T-47d, WM-115)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000065361-ERBB3

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Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magnetic bead

Bead Ligand
Anti-ERBB3 specific antibody

Target
ERBB3

Immunogen
Recombinant human ErbB3, aa 1-643.

Target Species
Human

Bead Capacity
40 mg/mL

Bead size
25 μm

Format
Suspension

Concentration
2 mg/mL

Buffer
PBS, pH 7.4

Preservative
0.1% Sodium azide

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Alternative Names
Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; Receptor Tyrosine-Protein Kinase ErbB-3; P180-ErbB3;

Gene ID
2065

UniProt ID
P21860

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0724-YC1400.pdf

MSDS

MSDS - VS-0724-YC1400.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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CAT	Product Name	Application	Type
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TAB-0035CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0035CL)	ELISA, FuncS, Inhib, FC	Human IgG
TAB-0036CL	Human Anti-ERBB3 Recombinant Antibody (TAB-0036CL)	ELISA, FuncS, Inhib, FC	Human IgG
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CAT	Product Name	Application	Type
TAB-0552CL-S(P)	Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0552CL-S(P))	ELISA, Inhib	Mouse scFv
TAB-0553CL-S(P)	Mouse Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-0553CL-S(P))	ELISA, Inhib	Mouse scFv
TAB-0552CL-F(E)	Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0552CL-F(E))	ELISA, Inhib	Mouse Fab
TAB-0553CL-F(E)	Mouse Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-0553CL-F(E))	ELISA, Inhib	Mouse Fab
TAB-060CT	Rabbit Anti-ERBB3 Recombinant Antibody (TAB-060CT)	Inhib, ELISA	Rabbit IgG

CAT	Product Name	Application	Type
TAB-057CT	Human Anti-ERBB3 Recombinant Antibody (TAB-057CT)	Inhibion, ELISA	Humanized antibody
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TAB-063CT	Human Anti-ERBB3 Recombinant Antibody (TAB-063CT)	IF, WB, Inhib, ELISA	Humanized antibody
TAB-063CT-F(E)	Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-063CT-F(E))	ELISA, Inhib, FC	Humanized Fab

CAT	Product Name	Application	Type
TAB-061CT	Human Anti-ERBB3 Recombinant Antibody (TAB-061CT)	Inhib, ELISA	Chimeric (Rabbit/Human) antibody
TAB-061CT-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (TAB-061CT-S(P))	Inhib, ELISA	Human scFv
TAB-061CT-F(E)	Human Anti-ERBB3 Recombinant Antibody; Fab Fragment (TAB-061CT-F(E))	Inhib, ELISA	Chimeric (Rabbit/Human) Fab

CAT	Product Name	Application	Type
NEUT-738CQ	Mouse Anti-ERBB3 Recombinant Antibody (clone CBL932)	Neut, IP	Mouse IgG1
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CAT	Product Name	Application	Type
MOR-1179	Hi-Affi™ Rabbit Anti-ERBB3 Recombinant Antibody (clone DS1179AB)	ICC, IF, WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0081-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0081-FY-S(P))	Inhib	Human scFv
HPAB-0120-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0120-FY-S(P))	ELISA, WB	Human scFv
HPAB-0128-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0128-FY-S(P))	ELISA	Human scFv
HPAB-0181-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0181-FY-S(P))	FC	Human scFv
HPAB-0182-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody; scFv Fragment (HPAB-0182-FY-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-H21	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H21)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody
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AFC-TAB-189	Afuco™ Anti-ERBB3 Recombinant Antibody (AFC-TAB-189), ADCC Enhanced	IP, IF, FuncS, FC, Neut, ELISA	Human IgG1, κ
AFC-TAB-H22	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H22)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-892	Afuco™ Anti-ERBB3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-892)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0724-FY-S(P)	Mouse Anti-ERBB3 Recombinant Antibody (clone AB062); Fab Fragment	ELISA	Mouse Fab
HPAB-0783-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody (clone Hu-Lc9); Fab Fragment	ELISA	Human Fab
HPAB-0784-FY-S(P)	Human Anti-ERBB3 Recombinant Antibody (clone Hu-2Hl); Fab Fragment	ELISA	Human Fab
HPAB-0806-FY-S(P)	Mouse Anti-ERBB3 Recombinant Antibody scFv Fragment (HPAB-0806-FY-S(P))	Inhib	Mouse scFv
HPAB-0807-FY-S(P)	Mouse Anti-ERBB3 Recombinant Antibody scFv Fragment (HPAB-0807-FY-S(P))	Inhib	Mouse scFv

CAT	Product Name	Application	Type
VS-0424-XY92	AbPlus™ Anti-ERBB3 Magnetic Beads (Duligotuzumab)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY22	Human Anti-ERBB3 (clone H3) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc
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CAT	Product Name	Application	Type
VS-0425-YC478	Recombinant Anti-ERBB3 Vesicular Antibody, EV Displayed (VS-0425-YC478)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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