Anti-EZH2 (clone W24V178) Recombinant Antibody Coupled Liposome (VS-1024-FY179)
CAT#: VS-1024-FY179
The use of anti-EZH2 antibody conjugated liposomes in melanoma therapy targets the enhancer of zeste homolog 2 (EZH2), a pivotal protein in the epigenetic regulation of gene expression that promotes tumor progression. By selectively delivering therapeutic agents to cancer cells expressing high levels of EZH2, these liposomes aim to disrupt the oncogenic signaling pathways that contribute to tumor development and resistance to treatment. This innovative approach not only enhances the specificity of the therapy but also minimizes potential side effects associated with conventional treatments, ultimately improving patient outcomes in melanoma management.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SiHa
Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29131/2008_C2_16_cr5f1a9e9d6c53d_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9589/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29131/2027_D2_1_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29131/582_H8_1_red_green.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9589/23664_A_9_3.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9589/23664_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9589/23664_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106462-EZH2
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More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- W24V178
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse monoclonal antibody that was specifically designed to target the Enhancer of Zeste Homolog 2 (EZH2) protein. EZH2 is a critical component of the Polycomb Repressive Complex 2 (PRC2) and plays a significant role in gene regulation, particularly in the context of stem cell development and oncogenesis.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- EZH2
- Introduction
- This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein.
- Alternative Names
- WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2
- Full Name
- Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit
- Gene ID
- 2146
- UniProt ID
- Q15910
- Sequence Similarities
- Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family.
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated by AKT1.
Phosphorylation by AKT1 reduces methyltransferase activity.
Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing.
- Protein Refseq
- XP_005250019.1; XP_005250020.1; XP_005250021.1; XP_011514185.1; XP_011514187.1
- Function
- Polycomb group (PcG) protein.
Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene.
Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.
Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0> H3K27me1> H3K27me2.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
- CAT
- Product Name
See other products for "EZH2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC078 | PE-A*02:01/Human EZH2 (YMCSFLFNL) MHC Tetramer | FCM | |
| MHC-LC079 | APC-A*02:01/Human EZH2 (YMCSFLFNL) MHC Tetramer | FCM | |
| MHC-LC080 | BV421-A*02:01/Human EZH2 (YMCSFLFNL) MHC Tetramer | FCM | |
| MHC-CN0657 | PE-A*02:01/Human EZH2 (SQADALKYV) MHC Tetramer | FCM, IHC | |
| MHC-YF275 | A*02:01/Human EZH2 (YMCSFLFNL) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1221 | Hi-Affi™ Rabbit Anti-EZH2 Recombinant Antibody (clone DS1221AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0905-CN | Rabbit Anti-EZH2 Recombinant Antibody (clone CBACN-338) | WB, IF, IHC | Rabbit IgG |
| VS3-QX394 | Mouse Anti-EZH2 Recombinant Antibody (clone 3D2A4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-QX395 | Mouse Anti-EZH2 Recombinant Antibody (clone 144CT2.1.1.5) | WB, ICC, IHC | Mouse IgG1, κ |
| VS3-QX396 | Mouse Anti-EZH2 Recombinant Antibody (clone 6F-4G) | WB, IHC, FC | Mouse IgG1 |
| VS3-FY526 | Recombinant Rabbit Anti-EZH2 Antibody (clone R07-5B1) | WB, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY197 | Mouse Anti-NHP EZH2 Recombinant Antibody (clone H.547.3) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2396 | Anti-EZH2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2397 | Anti-Mouse EZH2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2398 | Anti-Rat EZH2 Immunohistochemistry Kit | IHC |
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