Human Anti-F8 Recombinant Antibody (clone KM33)
CAT#: FAMAB-0197-CN
The monoclonal antibody KM33 acts as a high-affinity ligand that can inhibit the function of blood coagulation factor VIII (FVIII). In vitro, KM33 inhibits FVIII activity and interactions with its physiological ligands, von Willebrand factor, phospholipids and catabolic receptors.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category:Cell line enhanced (U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185010-F8
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human F8
- Species Reactivity
- Human
- Clone
- KM33
- Applications
- WB
- Related Disease
- Hemophilia A
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot, Flow Cytometry and Inhibition.
Target
- Alternative Names
- Coagulation Factor VIII; Coagulation Factor VIII, Procoagulant Component; Antihemophilic Factor; F8C; AHF; Coagulation Factor VIII A1 Domain; Coagulation Factor VIII C2 Domain; Coagulation Factor VIIIc; Procoagulant Component; Factor VIII F8B; Factor VIIIF8B; Hemophilia A; DXS1253E; FVIII; HEMA; F8B
- Gene ID
- 2157
- UniProt ID
- P00451
REVIEWS AND Q&AS
CITATIONS
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Highly Reproducible Results
Results are highly reproducible, making it a reliable tool in our antibody arsenal.
Perfect for Research Use
For anyone in need of a reliable research-grade antibody, this is an excellent choice.
Quick Delivery
Delivery was prompt, and the packaging ensured the antibody arrived in perfect condition.
Q&As
-
How do I titrate this antibody for my experiment?
A: Start with a dilution range of 1:100 to 1:5000 and adjust according to the needs of your particular experiment. Determine the optimal concentration by first conducting a small-scale test.
-
How do I confirm the specificity of the antibody?
A: Utilizing known positive and negative samples, do control studies. Specificity can be verified with the aid of immunoprecipitation and Western blot.
-
Are there special handling instructions for this antibody?
A: Once the antibody has thawed, handle it on ice or at 4°C. Steer clear of being overly agitated. Before used, a quick centrifuge might help extract as much antibody as possible from the vial.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone KM33"
- CAT
- Product Name
See other products for "F8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-930-VHH | Recombinant Anti-Human F8 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259CL | Human Anti-F8 Recombinant Antibody (TAB-259CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-044 | Human Anti-F8 Recombinant Antibody (clone BO2C11); scFv Fragment | Neut | Human scFv |
| HPAB-1977-FY-S(P) | Human Anti-F8 Recombinant Antibody (clone 92-137); scFv Fragment | Inhib | Human scFv |
| HPAB-1978-FY-S(P) | Human Anti-F8 Recombinant Antibody (clone 92-102); scFv Fragment | Inhib | Human scFv |
| FAMAB-0200JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM41); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-1613WJ-S(P) | Human Anti-F8 Recombinant Antibody; scFv Fragment (clone KRIX 1) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-014LC | Recombinant Anti-Human F8 Antibody (Fab glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0376MZ | Recombinant Mouse Anti-Human Factor VIII Antibody (clone BIWIV-5026) | WB, ELISA | Mouse antibody |
| HPAB-0096-YC | Human Anti-F8 Recombinant Antibody (clone YK3.3.38) | ELISA, FuncS | Human IgG |
| FAMAB-0037JF | Human Anti-F8 Recombinant Antibody (clone MH8) | WB, IF, IHC, Inhib, FuncS | Human IgG |
| FAMAB-0038JF | Human Anti-F8 Recombinant Antibody (clone DH10) | WB, IF, ELISA, Dot | Human IgG |
| FAMAB-0039JF | Human Anti-F8 Recombinant Antibody (clone JM4) | IP, ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
| PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
| PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
| MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
| MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0096-YC-F(E) | Human Anti-F8 Recombinant Antibody (clone YK3.3.38); Fab Fragment | ELISA, FuncS | Human Fab |
| HPAB-1977-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-137); Fab Fragment | Inhib | Human Fab |
| HPAB-1978-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone 92-102); Fab Fragment | Inhib | Human Fab |
| FAMAB-0200JF-F(E) | Human Anti-F8 Recombinant Antibody (clone KM41); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-1613WJ-F(E) | Human Anti-F8 Recombinant Antibody; Fab Fragment (clone KRIX 1) | ELISA, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY94 | AbPlus™ Anti-F8 Magnetic Beads (JM4) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY172 | Human Anti-F8 (clone BO2C11) scFv-Fc Chimera | Inhib, ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC76 | Recombinant Anti-F8 (A2 domain x C1 domain) Biparatopic Antibody, Tandem scFv (Clone JM4 x Clone KM33) | ELISA | Tandem scFv |
| VS-0525-YC78 | Recombinant Anti-F8 (AA 484-508 x AA 712-736) Biparatopic Antibody, Tandem scFv (Clone VK34 x Clone VK41) | ELISA | Tandem scFv |
| VS-0525-YC80 | Recombinant Anti-F8 (AA 1803-1818 x AA 2223-2332) Biparatopic Antibody, Tandem scFv (Clone KM41 x Clone WR8) | ELISA | Tandem scFv |
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