Anti-FCGR2A (clone 2B6) Recombinant Antibody Coupled Liposome (VS-1024-FY268) (CAT#: VS-1024-FY268)

• Potential Clinical Applications
• The specific potential of anti-CD32 immunoliposomes for the treatment of leukemia.

• Clone
• 2B6

• Antibody Type
• IgG1, kappa

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant mouse antibody specifically designed to recognize the Fc-gamma receptor IIb (Fc fragment of IgG receptor IIb). It was expressed in mammalian cells using chemically defined culture media and has been purified via affinity chromatography to ensure high purity and specificity.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FCGR2A

• Introduction
• This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

• Alternative Names
• Fc Fragment Of IgG Receptor IIa; Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32); Immunoglobulin G Fc Receptor II; IgG Fc Receptor II-A; Fc-Gamma-RIIa; FcRII-A; FCGR2A1; CDw32; IGFR2; FCG2

• Full Name
• Fc Fragment Of IgG Receptor IIa

• Gene ID
• 2212

• UniProt ID
• P12318

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.

• Protein Refseq
• NP_001129691.1; NP_067674.2

• Function
• Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

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