Anti-FCGR2A (clone 2B6) Recombinant Antibody Coupled Liposome (VS-1024-FY268)
CAT#: VS-1024-FY268
Anti-CD32 liposomes are a drug delivery system that harnesses the specific binding of anti-CD32 antibodies to enhance the targeting and efficacy of therapeutic drugs in specific cells, such as leukemia cells expressing the corresponding receptor. This approach enables effective drug loading and increases the potential applications of the therapy in tumor immunotherapy.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line THP-1
Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10776/1926_F1_3_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong positivity in endothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14730/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10776/1847_F1_2_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10718/26353_B_4_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HEL, HMC-1, K-562, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143226-FCGR2A
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More Infomation
Specifications
- Potential Clinical Applications
- The specific potential of anti-CD32 immunoliposomes for the treatment of leukemia.
Product Composition
- Clone
- 2B6
- Antibody Type
- IgG1, kappa
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This product is a recombinant mouse antibody specifically designed to recognize the Fc-gamma receptor IIb (Fc fragment of IgG receptor IIb). It was expressed in mammalian cells using chemically defined culture media and has been purified via affinity chromatography to ensure high purity and specificity.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FCGR2A
- Introduction
- This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.
- Alternative Names
- Fc Fragment Of IgG Receptor IIa; Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32); Immunoglobulin G Fc Receptor II; IgG Fc Receptor II-A; Fc-Gamma-RIIa; FcRII-A; FCGR2A1; CDw32; IGFR2; FCG2
- Full Name
- Fc Fragment Of IgG Receptor IIa
- Gene ID
- 2212
- UniProt ID
- P12318
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
- Protein Refseq
- NP_001129691.1; NP_067674.2
- Function
- Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
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Datasheet
MSDS
COA
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