Recombinant Anti-FGFR3 (Domain 2 x Domain 3c) Biparatopic Antibody, Tandem scFv (Clone PRO-001 x Clone PRO-055) (CAT#: VS-0525-YC82)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human FGFR3

• Species Reactivity
• Human, Mouse

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• PRO-001

• Clone 2
• PRO-055

• Epitope 1
• Domain 2 of FGFR3

• Epitope 2
• Domain 3c of FGFR3

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• FC

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Fibroblast Growth Factor Receptor 3

• Introduction
• This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

• Alternative Names
• Fibroblast Growth Factor Receptor 3; EC 2.7.10.1; FGFR-3; JTK4; Fibroblast Growth Factor Receptor 3 Variant 4; Achondroplasia, Thanatophoric Dwarfism; Hydroxyaryl-Protein Kinase; Tyrosine Kinase JTK4; CD333 Antigen; HSFGFR3EX; EC 2.7.10; CD333; CEK2; ACH

• Gene ID
• 2261

• UniProt ID
• P22607

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