Anti-FGFR4 (clone 10F10) Recombinant Antibody Coupled Liposome (VS-1024-FY181) (CAT#: VS-1024-FY181)

• Potential Clinical Applications
• Melanoma

• Clone
• 10F10

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This human monoclonal antibody is specifically engineered to attach to the FGFR4 receptor. FGFR4 is a significant player in cellular signaling pathways, impacting developmental processes and tissue repair. The targeted binding provided by this antibody enhances its application in cancer research, particularly in studies related to hepatocellular carcinoma and muscle regeneration.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FGFR4

• Introduction
• The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.

• Alternative Names
• CD334; JTK2; TKF

• Full Name
• Fibroblast Growth Factor Receptor 4

• Gene ID
• 2264

• UniProt ID
• P22455

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Cell membrane, Endosome, Endoplasmic reticulum

• Post Translation Modifications
• N-glycosylated, Ubiquitinated, Autophosphorylated, Glycosylation at Asn112, Asn258, Asn290, Asn311, Asn322, and Asn508

• Protein Refseq
• NP_001278909.1; NP_001341913.1; NP_002002.3; NP_075252.2; NP_998812.1

• Function
• Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.

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