Anti-FGFR4 (clone 10F10) Recombinant Antibody Coupled Liposome (VS-1024-FY181)
CAT#: VS-1024-FY181
FGFR4 is involved in cell proliferation and migration in melanoma. The anti-FGFR4 antibody conjugated liposome targets and inhibits these pathways, potentially reducing tumor growth. This targeted delivery system enhances the therapeutic efficacy of the treatment. Preclinical studies demonstrate promising results in shrinking melanoma tumors.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human gall bladder
Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4
❮
❯
More Infomation
Specifications
- Potential Clinical Applications
- Melanoma
Product Composition
- Clone
- 10F10
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This human monoclonal antibody is specifically engineered to attach to the FGFR4 receptor. FGFR4 is a significant player in cellular signaling pathways, impacting developmental processes and tissue repair. The targeted binding provided by this antibody enhances its application in cancer research, particularly in studies related to hepatocellular carcinoma and muscle regeneration.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FGFR4
- Introduction
- The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
- Alternative Names
- CD334; JTK2; TKF
- Full Name
- Fibroblast Growth Factor Receptor 4
- Gene ID
- 2264
- UniProt ID
- P22455
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Cell membrane, Endosome, Endoplasmic reticulum
- Post Translation Modifications
- N-glycosylated, Ubiquitinated, Autophosphorylated, Glycosylation at Asn112, Asn258, Asn290, Asn311, Asn322, and Asn508
- Protein Refseq
- NP_001278909.1; NP_001341913.1; NP_002002.3; NP_075252.2; NP_998812.1
- Function
- Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1024-FY181. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "FGFR4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-066WM | Anti-Human FGFR4 Recombinant Antibody (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-066WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (XPA.48.056) | ELISA, FC | Human Antibody |
| TAB-384CQ | Human Anti-FGFR4 Recombinant Antibody (TAB-384CQ) | ELISA | Human IgG |
| TAB-384CQ-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (TAB-384CQ-S(P)) | ELISA | Human scFv |
| TAB-384CQ-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (TAB-384CQ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067WM | Anti-Human FGFR4 Recombinant Antibody (F85-6C5) | IP, ELISA | |
| TAB-068WM | Mouse Anti-FGFR4 Recombinant Antibody (TAB-068WM) | ELISA, WB | Mouse IgG |
| TAB-069WM | Rat Anti-FGFR4 Recombinant Antibody (TAB-069WM) | ELISA, WB, FC, Inhib | Rat IgG |
| TAB-065WM-F(E) | Mouse Anti-FGFR4 Recombinant Antibody; Fab Fragment (TAB-065WM-F(E)) | ELISA, FC | Mouse Fab |
| TAB-067WM-F(E) | Anti-Human FGFR4 Recombinant Antibody Fab Fragment (F85-6C5) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0739CT | Recombinant Mouse anti-Human FGFR4 Monoclonal antibody (NN0390-7I44) | WB | |
| HPAB-0054-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0054-LS) | Inhib | Human IgG |
| HPAB-0055-LS | Human Anti-FGFR4 Recombinant Antibody (HPAB-0055-LS) | Inhib | Human IgG |
| ZG-0344J | Mouse Anti-FGFR4 Recombinant Antibody (ZG-0344J) | WB, IF, ELISA | Mouse IgG |
| ZG-0345J | Mouse Anti-FGFR4 Recombinant Antibody (ZG-0345J) | WB, IHC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1300 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone DS1300AB) | WB | Rabbit IgG |
| MOR-4575 | Hi-Affi™ Rabbit Anti-FGFR4 Recombinant Antibody (clone TH87DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0054-LS-S(P)) | Inhib | Human scFv |
| HPAB-0055-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0055-LS-S(P)) | Inhib | Human scFv |
| HPAB-0056-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0056-LS-S(P)) | Inhib | Human scFv |
| HPAB-0057-LS-S(P) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); scFv Fragment | Inhib, ELISA, WB | Human scFv |
| HPAB-0442-FY-S(P) | Human Anti-FGFR4 Recombinant Antibody; scFv Fragment (HPAB-0442-FY-S(P)) | Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0054-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0054-LS-F(E)) | Inhib | Human Fab |
| HPAB-0055-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0055-LS-F(E)) | Inhib | Human Fab |
| HPAB-0056-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-0056-LS-F(E)) | Inhib | Human Fab |
| HPAB-0057-LS-F(E) | Human Anti-FGFR4 Recombinant Antibody (clone XPA.48.117); Fab Fragment | Inhib, ELISA, WB | Human Fab |
| HPAB-2922LY-F(E) | Mouse Anti-FGFR4 Recombinant Antibody; Fab Fragment (HPAB-2922LY-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-028CN | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1) | ELISA, WB, FC, IHC, IP | Mouse IgG1 |
| NS-028CN-F(E) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); Fab Fragment | ELISA, WB, FC, IHC, IP | Mouse Fab |
| NS-028CN-S(P) | Mouse Anti-FGFR4 Recombinant Antibody (clone LD1); scFv Fragment | ELISA, WB, FC, IHC, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF433 | A*02:01/Human FGFR4 (ALLAGLVSL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY103 | AbPlus™ Anti-FGFR4 Magnetic Beads (F85-6C5) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC308 | Recombinant Anti-FGFR4 Vesicular Antibody, EV Displayed (VS-0425-YC308) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2545 | Anti-FGFR4 Immunohistochemistry Kit | IHC |
See Our Custom Production in Action
Popular Products
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, IP, IF, FuncS, FC, Neut, ELISA
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: FC, FRET, Internalization
Application: ELISA, IHC, FC, IP, IF, FuncS
-2.png)
Application: ELISA
Application: Neut, FuncS, IHC, ELISA, FC, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
