What is the specificity of this recombinant antibody?

This recombinant human antibody specifically recognizes human FGFR4 (Fibroblast Growth Factor Receptor 4). It is produced in mammalian cells to ensure proper folding and reactivity.

Can this antibody be used for inhibition studies?

Yes, this antibody has been tested for use in Inhibition (Inhib) assays. It binds to FGFR4 and can modulate its function, making it useful for studying receptor signaling pathways.

Human Anti-FGFR4 Recombinant Antibody (HPAB-0442-FY)

CAT#: HPAB-0442-FY

This product is a recombinant human antibody that recognizes FGFR4. The antibody was expressed in mammalian cells with chemically defined culture media and was purified by affinity chromatography.

Gene Expression

Normal Tissue Figure 1 IHC staining of human smooth muscle

Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27273/ihc_selected.jpg

Normal Tissue Figure 2 IHC staining of human gall bladder

Immunohistochemical staining of human gall bladder shows strong cytoplasmic and membrane positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/ihc_selected.jpg

Normal Tissue Figure 3 IHC staining of human prostate

Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5196/ihc_selected.jpg

Normal Tissue Figure 4 Colon

Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_3.jpg

Normal Tissue Figure 5 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_7_5.jpg

Normal Tissue Figure 7 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28251/61139_A_4_6.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (CACO-2, Hep G2, RH-30)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000160867-FGFR4

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Specifications

Host Species
Human

Type
Human IgG

Specificity
Human FGFR4

Species Reactivity
Human

Applications
Inhib

Related Disease
Heart hypertrophy or chronic kidney disease

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Fibroblast Growth Factor Receptor 4; EC 2.7.10.1; JTK2; TKF; Tyrosine Kinase Related To Fibroblast Growth Factor Receptor; Hydroxyaryl-Protein Kinase; Protein-Tyrosine Kinase;

Gene ID
2264

UniProt ID
P22455

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Breast cancer biomarkers at key points during disease progression

Effective Inhibition Tool

We used this recombinant human antibody for inhibition studies involving FGFR4. It demonstrated specific binding and effectively modulated the target in our assays. The quality is high, confirmed by SDS-PAGE, making it a reliable reagent for kinase research.

High Purity Recombinant

The purity of this anti-FGFR4 antibody is excellent. It recognizes human FGFR4 specifically. We are very pleased with the expression in mammalian cells using chemically defined media, ensuring a clean and consistent product for our biochemical assays.

Q&As

What is the specificity of this recombinant antibody?

A: This recombinant human antibody specifically recognizes human FGFR4 (Fibroblast Growth Factor Receptor 4). It is produced in mammalian cells to ensure proper folding and reactivity.
Can this antibody be used for inhibition studies?

A: Yes, this antibody has been tested for use in Inhibition (Inhib) assays. It binds to FGFR4 and can modulate its function, making it useful for studying receptor signaling pathways.

View the frequently asked questions answered by Creative Biolabs Support.

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0442-FY.pdf

MSDS

MSDS - HPAB-0442-FY.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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