Anti-FLT3 Antibody Prodrug, Protease Activated (VS-1025-YC22)
CAT#: VS-1025-YC22
The Anti-FLT3 Antibody Prodrug, Protease Activated (VS-1025-YC22) is an antibody prodrug comprised of a recombinant human antibody targeting human FLT3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to FLT3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to FLT3 effectively. FLT3 (FMS-like tyrosine kinase 3) is a receptor tyrosine kinase that is a major oncogenic driver in Acute Myeloid Leukemia (AML), most commonly through an internal tandem duplication (ITD) in its juxtamembrane domain. This mutation causes ligand-independent activation and unchecked proliferation of leukemic cells. Targeted FLT3 inhibitors are now standard of care for AML patients carrying this mutation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47539/1674_A6_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (REH, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122025-FLT3
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human FLT3
- Target
- FLT3
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
- Alternative Names
- Fms Related Tyrosine Kinase 3; Fms-Related Tyrosine Kinase 3; Stem Cell Tyrosine Kinase 1; Fms-Like Tyrosine Kinase 3; FL Cytokine Receptor; CD135 Antigen; EC 2.7.10.1; CD135; FLK-2; STK1; FLK2
- Gene ID
- 2322
- UniProt ID
- P36888
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Datasheet
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COA
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