AbPlus™ Anti-FLT3 Magnetic Beads (VS-0724-YC1172)
CAT#: VS-0724-YC1172
The AbPlus Anti-FLT3 Magnetic Beads (VS-0724-YC1172) is an innovative affinity resin which is bound with anti-FLT3 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of FLT3 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47539/1674_A6_32_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (REH, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000122025-FLT3
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-FLT3 specific antibody
- Target
- FLT3
- Immunogen
- Recombinant human FLT3, aa 1-200.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
- Alternative Names
- Fms Related Tyrosine Kinase 3; Stem Cell Tyrosine Kinase 1; Fms-Like Tyrosine Kinase 3; FL Cytokine Receptor; CD135 Antigen; EC 2.7.10.1; CD135; FLK-2; STK1; FLK2;
- Gene ID
- 2322
- UniProt ID
- P36888
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Datasheet
MSDS
COA
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