Rabbit Anti-FMR1 Recombinant Antibody (clone R08-5G5) (CAT#: VS3-FY1597)
The R08-5G5 recombinant monoclonal antibody detects human FMR1. It cross-reacts with monkey. The antibody is recommended for detection of FMR1 protein by WB, IHC-F, IHC-P, ICC/IF. The antibody has the positive detection of FMRP by western blot analysis of FMRP in 293, U2OS, Jurkat, COS7 lysates.
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WB
Figure 1 Anti-FMR1 Antibody (VS3-FY1597) in WB.
The FMRP expression in 293, U2OS, Jurkat, COS7 lysates were detected using the anti-FMR1 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human FMRP
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Monkey FMR1
- Species Reactivity
- Human, Monkey
- Clone
- R08-5G5
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 71 kDa, while the observed molecular weight stands at 70-80 kDa.
- Related Disease
- Fragile X Syndrome and Premature Ovarian Failure 1
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- Fragile X Mental Retardation 1; Fragile X Mental Retardation Protein 1; FMRP; Synaptic Functional Regulator FMR1; Premature Ovarian Failure 1; Protein FMR-1; FRAXA; POF1; POF
- Gene ID
- 2332
- UniProt ID
- Q06787
- Sequence Similarities
- Belongs to the FMR1 family.
- Cellular Localization
- Cell membrane, Cell projection, Centromere, Chromosome, Cytoplasm
- Post Translation Modifications
- Acetylation, Methylation, Phosphoprotein, Ubl conjugation
- Protein Refseq
- NP_001172004.1; NP_001172005.1; NP_001172010.1; NP_001172011.1; NP_002015.1
- Function
- Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors.
Plays a role in the alternative splicing of its own mRNA.
Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 and the myelin basic protein (MBP) mRNAs in hippocampal neurons and glial cells, respectively; this stabilization is further increased in response to metabotropic glutamate receptor (mGluR) stimulation (By similarity).
Plays a role in selective delivery of a subset of dendritic mRNAs to synaptic sites in response to mGluR activation in a kinesin-dependent manner (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2078MZ | Recombinant Mouse Anti-Fruit fly Drosophila melanogaster FMR1 Antibody (clone 7B26) | ELISA, ICC/IF, IP, WB | Mouse antibody |
| MRO-0596-CN | Rabbit Anti-FMR1 Recombinant Antibody (clone JM91-41) | WB, IF, IHC | Rabbit IgG |
| ZG-0354J | Mouse Anti-FMR1 Recombinant Antibody (ZG-0354J) | WB, IHC, IF, ELISA | Mouse IgG |
| VS3-XY716 | Mouse Anti-FMR1 Recombinant Antibody (clone 4G9) | ELISA, WB, IHC, ICC | Mouse IgG1 |
| VS13-YC407 | Rabbit Anti-FMR1 Recombinant Antibody (VS13-YC407) | WB, ICC, IF, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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