Anti-FN1 Antibody-Cytokine Fusion Protein, scFv (L19)-TNF
CAT#: VS-0624-FY91
The L19 antibody is a human antibody that specifically targets the EDB domain of fibronectin. This antibody has been extensively utilized as a molecular tool for the targeted delivery of radioisotopes or cytokines in the fields of cancer imaging and therapy. Onfekafusp alfa (L19TNF) is a homotrimer composed of an engineered peptide from the L19 antibody fused to human TNF in a scFv format. Onfekafusp alfa is indicated for use in malignant glioma research.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1
❮
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Specifications
- Target
- EDB domain of fibronectin
- Molecule Class
- scFv-TNF
- Species Reactivity
- Human
- Clone
- L19
- Related Disease
- Inflammatory diseases, psoriasis, Crohn's disease
- Cytokine 1
- TNF
- Cytokines 1 Description
- Tumor necrosis factor (TNF, cachexia, or cachexia; formerly known as tumor necrosis factor alpha or TNF-α) is a cytokine that belongs to the TNF superfamily, which consists of various transmembrane proteins with homologous TNF domains. It was the first cytokine described as an adipokine secreted by adipose tissue.
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.
- Alternative Names
- Fibronectin 1; Cold-Insoluble Globulin; Migration-Stimulating Factor; CIG; FN; Fibronectin; GFND2; SMDCF; Onfekafusp alfa
- Gene ID
- 2335
- UniProt ID
- P02751
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Homotrimer Structure Utility
The homotrimeric structure of Onfekafusp alfa (L19TNF) is very stable. We utilize this reagent for targeting radioisotopes and cytokines in our malignant glioma research, and it consistently binds the EDB domain with high specificity.
Effective For Imaging
We have extensively used the L19 antibody part of this fusion as a molecular tool for cancer imaging. The TNF fusion adds a functional layer allowing us to study effects on vasculature in embryogenesis and wound healing models.
Q&As
-
What is the structure of Onfekafusp alfa?
A: Onfekafusp alfa (L19TNF) is a homotrimer composed of an engineered peptide from the L19 antibody fused to human TNF in an scFv format. It specifically targets the EDB domain of fibronectin.
-
What are the applications of the L19 antibody component?
A: The L19 antibody is a human antibody that specifically targets the EDB domain of fibronectin. It has been extensively utilized as a molecular tool for the targeted delivery of radioisotopes or cytokines in the fields of cancer imaging and therapy research.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
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COA
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