Anti-FN1 Antibody-Cytokine Fusion Protein, scFv (L19)-TNF
CAT#: VS-0624-FY91
The L19 antibody is a human antibody that specifically targets the EDB domain of fibronectin. This antibody has been extensively utilized as a molecular tool for the targeted delivery of radioisotopes or cytokines in the fields of cancer imaging and therapy. Onfekafusp alfa (L19TNF) is a homotrimer composed of an engineered peptide from the L19 antibody fused to human TNF in a scFv format. Onfekafusp alfa is indicated for use in malignant glioma research.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1
❮
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Specifications
- Target
- EDB domain of fibronectin
- Molecule Class
- scFv-TNF
- Species Reactivity
- Human
- Clone
- L19
- Related Disease
- Inflammatory diseases, psoriasis, Crohn's disease
- Cytokine 1
- TNF
- Cytokines 1 Description
- Tumor necrosis factor (TNF, cachexia, or cachexia; formerly known as tumor necrosis factor alpha or TNF-α) is a cytokine that belongs to the TNF superfamily, which consists of various transmembrane proteins with homologous TNF domains. It was the first cytokine described as an adipokine secreted by adipose tissue.
- Cytokine 1 Species
- Human
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.
- Alternative Names
- Fibronectin 1; Cold-Insoluble Globulin; Migration-Stimulating Factor; CIG; FN; Fibronectin; GFND2; SMDCF; Onfekafusp alfa
- Gene ID
- 2335
- UniProt ID
- P02751
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Related Diseases
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
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Lot Number:
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0105-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone ME4C); scFv Fragment | ELISA, IHC | Human scFv |
| HPAB-1705-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02610); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1706-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02611); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1707-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02613); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-S0037-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment | ELISA, IB, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1110-FY) | IHC | Human IgG |
| HPAB-1111-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1111-FY) | IHC | Human IgG |
| HPAB-1112-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1112-FY) | IHC | Human IgG |
| HPAB-1113-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1113-FY) | IHC | Human IgG |
| HPAB-1114-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1114-FY) | IHC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1705-FY-S(P) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02610); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1706-FY-S(P) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02611); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-1707-FY-S(P) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02613); Fab Fragment | ELISA, IHC | Mouse Fab |
| HPAB-S0037-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); Fab Fragment | ELISA, IB, IHC | Human Fab |
| HPAB-S0038-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone L19); Fab Fragment | ELISA, IF, IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NBD-0040-YJ-VHH) | ELISA, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY105 | AbPlus™ Anti-FN1 Magnetic Beads (HFN7.1) | IP, Protein Purification | |
| VS-0724-YC853 | AbPlus™ Anti-FN1 Magnetic Beads (VS-0724-YC853) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY204 | Mouse Anti-NHP FN1 Recombinant Antibody (clone C6F10) | WB, IHC, IF, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY108 | Human Anti-FN1 (clone L19) scFv-Fc Chimera | IHC, ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2593 | Anti-FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2594 | Anti-Rat FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2595 | Anti-Mouse FN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC87 | Recombinant Anti-FN1 ED-B (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone CGS-2 x Clone CGS-1) | ELISA | Tandem scFv |
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