Anti-FN1 Antibody-Cytokine Fusion Protein, scFv (L19)-TNF (CAT#: VS-0624-FY91)

• Target
• EDB domain of fibronectin

• Molecule Class
• scFv-TNF

• Species Reactivity
• Human

• Clone
• L19

• Related Disease
• Inflammatory diseases, psoriasis, Crohn's disease

• Cytokine 1
• TNF

• Cytokines 1 Description
• Tumor necrosis factor (TNF, cachexia, or cachexia; formerly known as tumor necrosis factor alpha or TNF-α) is a cytokine that belongs to the TNF superfamily, which consists of various transmembrane proteins with homologous TNF domains. It was the first cytokine described as an adipokine secreted by adipose tissue.

• Cytokine 1 Species
• Human

• Applications
• This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

• Alternative Names
• Fibronectin 1; Cold-Insoluble Globulin; Migration-Stimulating Factor; CIG; FN; Fibronectin; GFND2; SMDCF; Onfekafusp alfa

• Gene ID
• 2335

• UniProt ID
• P02751

• ACFP-SH081
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