Human Anti-FN1 Recombinant Antibody (clone G4) (CAT#: FAMAB-1143CQ)
This product is a recombinant human antibody that recognizes FN1. The antibody was purified by affinity chromatography. It can be used in WB, ELISA, IHC-Fr.
Specific Inquiry
IHC
Figure 1 Extradomain-B Fibronectin (EDB-FN) overexpression in invasive breast cancer.
Strong EDB-FN staining observed in adjacent tissue (NAT), and metastases in lung.
Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.
IF
Figure 2 Extradomain-B Fibronectin (EDB-FN) overexpression in invasive breast cancer.
3D cultures of the cancer cell lines stained with EDB-FN-specific ZD2-Cy5.5 probe show higher EDB-FN expression in the invasive cell lines than in MCF7 cells, demonstrating direct correlation with their invasive pattern.
Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.
WB
Figure 3 Depletion of EDB-FN and SRp55 in invasive TGF-β-treated and drug-resistant breast cancer cells reduces their invasion.
TGF-β-treated and drug-resistant MCF7 and MDA-MB-468 cells were treated with ECO/siNC (siN), ECO/siEDB (siE), and ECO/siSRSF6 (siS) nanoparticles at 100 nM [siRNA] and N/P = 10.
Vaidya, A., Wang, H., Qian, V., Gilmore, H., & Lu, Z. R. (2020). Overexpression of extradomain-B fibronectin is associated with invasion of breast cancer cells. Cells, 9(8), 1826.
Specifications
- Immunogen
- Human Extra-Domain containing fibronectin
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human Extra-Domain containing fibronectin
- Species Reactivity
- Human
- Clone
- G4
- Applications
- IF, WB, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunofluorescence, Western Blot and Immunohistochemistry.
Target
- Alternative Names
- Fibronectin 1; Cold-Insoluble Globulin; Migration-Stimulating Factor; CIG; FN; Fibronectin; GFND2; SMDCF
- Gene ID
- 2335
- UniProt ID
- P02751
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193 | Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | [(scFv - heavy - kappa) - IGHE - CH4]2 |
| TAB-001CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
| TAB-002CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (ME-4C) | ELISA, IHC | Human antibody |
| TAB-003CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (1C5) | ELISA, WB | Human antibody |
| TAB-071WM-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (CGS-1) | ELISA, WB | Human Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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