Mouse Anti-FOLH1 Recombinant Antibody (clone 1F12) (CAT#: VS3-WK1599)
This antibody is a mouse recombinant antibody against human FOLH1, which acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. The clone 1F12 can be used in IHC analysis at a dilution of 1/50-1/200.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Figure 2 Prostate
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Specifications
- Immunogen
- Synthesized peptide derived from human PSMA
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human FOLH1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 1F12
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- IHC: 1/50-1/200
Target
- Alternative Names
- Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII
- Gene ID
- 2346
- UniProt ID
- Q04609
- Long Name
- Folate Hydrolase 1
- Sequence Similarities
- Belongs to the peptidase M28 family. M28B subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm
- Post Translation Modifications
- The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.
- Protein Refseq
- NP_001014986.1
- Function
- Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "FOLH1"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1169z-S(P) | Recombinant Anti-Human FOLH1 Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| HPAB-1708-FY-F(E) | Human Anti-FOLH1 Recombinant Antibody; Fab Fragment (HPAB-1708-FY-F(E)) | Cyt | Human Fab |
| HPAB-1710-FY-F(E) | Human Anti-FOLH1 Recombinant Antibody; Fab Fragment (HPAB-1710-FY-F(E)) | Cyt | Human Fab |
| HPAB-1154WJ-S(P) | Mouse Anti-FOLH1 Recombinant Antibody (clone E99); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0115-YC-S(P) | Human Anti-FOLH1 Recombinant Antibody (clone V5); scFv Fragment | ELISA | Human scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-066 | Recombinant Anti-Human FOLH1 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-277CT | Anti-Human PSMA Therapeutic Single Domain Single Domain Antibody (TAB-277CT) | ELISA | Single domain antibody |
| HPAB-M0386-YC | Recombinant Camelid Anti-FOLH1 Single Domain Antibody (HPAB-M0386-YC) | ELISA | Camelid VHH |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G029E | Anti-FOLH1 immunotoxin D7 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G029D | Anti-FOLH1 immunotoxin D7 (scFv)-DT | Cytotoxicity assay, Function study |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-274CT-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (TAB-274CT-S(P)) | WB, ELISA, FC, IF, IHC | Mouse scFv |
| TAB-275CT-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (TAB-275CT-S(P)) | WB, ELISA, FC, IF, IHC | Mouse scFv |
| TAB-276CT-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (TAB-276CT-S(P)) | WB, ELISA, FC, IF, IHC | Mouse scFv |
| TAB-278CT-S(P) | Anti-Human PSMA Recombinant Antibody scFv Fragment (L-186) | WB, ELISA, IP, IF | |
| TAB-279CT-S(P) | Mouse Anti-FOLH1 Recombinant Antibody; scFv Fragment (TAB-279CT-S(P)) | FC, WB, ICC, SPR, IHC, IF, ELISA | Mouse scFv |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1332 | Hi-Affi™ Rabbit Anti-FOLH1 Recombinant Antibody (clone DS1332AB) | IHC-P | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC2502 | PE-B*07:02/Human FOLH1 (LPSIPVHPI) MHC Tetramer | FCM | |
| MHC-LC2503 | PE-B*35:01/Human FOLH1 (LPSIPVHPI) MHC Tetramer | FCM | |
| MHC-LC2504 | PE-B*51:01/Human FOLH1 (LPSIPVHPI) MHC Tetramer | FCM | |
| MHC-LC2505 | PE-B*53:01/Human FOLH1 (LPSIPVHPI) MHC Tetramer | FCM | |
| MHC-YF277 | A*02:01/Human PSMA (VLAGGFFLL) MHC Monomer | MHC Multimer |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0184CQ-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone 2A10); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0185CQ-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone YC058); Fab Fragment | FC, IHC | Human Fab |
| HPAB-M0614-YC-F(E) | Human Anti-FOLH1 Recombinant Antibody; Fab Fragment (HPAB-M0614-YC-F(E)) | ELISA, FC, Cyt, FuncS | Human Fab |
| HPAB-M0092-YC-F(E) | Mouse Anti-FOLH1 Recombinant Antibody (clone 10B3); Fab Fragment | FC | Mouse Fab |
| HPAB-M0093-YC-F(E) | Human Anti-FOLH1 Recombinant Antibody (clone h10B3); Fab Fragment | FC | Humanized Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2142-CN | Rabbit Anti-FOLH1 Polyclonal Antibody (MRO-2142-CN) | WB, IF, FC | Rabbit IgG |
| HPAB-M0092-YC | Mouse Anti-FOLH1 Recombinant Antibody (clone 10B3) | FC | Mouse IgG |
| HPAB-M0093-YC | Human Anti-FOLH1 Recombinant Antibody (clone h10B3) | FC | Humanized IgG |
| HPAB-N0091-YC | Human Anti-FOLH1 Recombinant Antibody (HPAB-N0091-YC) | ELISA, FC, FuncS, Block | Human IgG |
| HPAB-N0092-YC | Human Anti-FOLH1 Recombinant Antibody (HPAB-N0092-YC) | ELISA, FC | Human IgG1, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-018 | Afuco™ Anti-FOLH1 ADCC Recombinant Antibody (Capromab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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