Human Anti-FOLH1 Recombinant Antibody (clone PI134) (CAT#: VS-0524-YC14)
The antibody binds to human prostate-specific membrane antigen (PSMA), also known as folate hydrolase 1 (FOLH1).
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Normal Tissue
RNA Expression
Figure 1 Kidney
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
(Proximal tubules (microvilli)
Staining: High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_7_5.jpg
Figure 2 Prostate
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
(Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1451/4354_A_2_5.jpg
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Figure 3 RNA cell line category: Cell line enhanced (HAP1, RPMI-8226, SK-BR-3, TIME, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000086205-FOLH1
Specifications
- Host Species
- Human
- Derivation
- M13 phage library
- Type
- Human IgG
- Specificity
- Human prostate-specific membrane antigen
- Species Reactivity
- Human
- Clone
- PI134
- Applications
- ELISA, FC
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservative
- Storage
- Centrifuge briefly prior to opening vial. Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1
- Gene ID
- 2346
- UniProt ID
- A4UU13
- Long Name
- Prostate-specific membrane antigen
- Sequence Similarities
- Belongs to the peptidase M28 family. M28B subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Membrane
- Post Translation Modifications
- The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. (Q04609-FOLH1_HUMAN)
The N-terminus is blocked. (Q04609-FOLH1_HUMAN)
Glycosylation at Asn76, Asn336, Asn51, Asn121, Asn140, Asn153, Asn195, Asn459, Asn476, and Asn638 (NX_Q04609 [NX_Q04609-1])
Modification sites at PhosphoSitePlus (Q04609)
Glycosylation from GlyGen (Q04609) 13 sites
- Protein Refseq
- XP_011518260.2; XP_016872921.1; XP_016872922.1; XP_016872923.1; XP_047282634.1
- Function
- Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1169z | Mouse Anti-FOLH1 Recombinant Antibody (MOB-1169z) | WB, FC, IHC, ICC, CyTOF | Mouse IgG2a |
| HPAB-M0092-YC | Mouse Anti-FOLH1 Recombinant Antibody (HPAB-M0092-YC) | FC | Mouse IgG |
| HPAB-M0093-YC | Human Anti-FOLH1 Recombinant Antibody (HPAB-M0093-YC) | FC | Humanized IgG |
| MOB-0224F | Mouse Anti-FOLH1 Recombinant Antibody (MOB-0224F) | IHC-P, IF | Mouse IgG |
| MOB-0225F | Mouse Anti-FOLH1 Recombinant Antibody (MOB-0225F) | IHC-P, IF | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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