Rabbit Anti-FOLH1 Recombinant Antibody (clone R09-4F8) (CAT#: VS3-FY1859)

• Immunogen
• Synthetic peptide of human PSMA

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse FOLH1

• Species Reactivity
• Human, Mouse

• Clone
• R09-4F8

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 84 kDa, while the observed molecular weight stands at 100 kDa.

• Related Disease
• Cancer

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII

• Gene ID
• 2346

• UniProt ID
• Q04609

• Sequence Similarities
• Belongs to the peptidase M28 family. M28B subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Membrane

• Post Translation Modifications
• The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. (Q04609-FOLH1_HUMAN)
  The N-terminus is blocked. (Q04609-FOLH1_HUMAN)
  Glycosylation at Asn76, Asn336, Asn51, Asn121, Asn140, Asn153, Asn195, Asn459, Asn476, and Asn638 (NX_Q04609 [NX_Q04609-1])
  Modification sites at PhosphoSitePlus (Q04609)
  Glycosylation from GlyGen (Q04609) 13 sites

• Protein Refseq
• XP_011518260.2; XP_016872921.1; XP_016872922.1; XP_016872923.1; XP_047282634.1

• Function
• Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
  Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody