Anti-FSTL1 (clone W24V97) Recombinant Antibody Coupled Liposome (VS-1024-FY99) (CAT#: VS-1024-FY99)

• Potential Clinical Applications
• Glioma

• Clone
• W24V97

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This represents a recombinant human monoclonal antibody that was designed to specifically target and bind to human FSTL1 (Follistatin-like 1). FSTL1 is a glycoprotein that plays a crucial role in various biological processes, including inflammation, tissue repair, and cellular signaling. By specifically recognizing FSTL1, this antibody can be utilized for a variety of applications in research and therapeutic contexts.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FSTL1

• Introduction
• Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.

• Alternative Names
• FRP; FSL1; OCC1; OCC-1; tsc36; MIR198

• Full Name
• Follistatin Like 1

• Gene ID
• 11167

• UniProt ID
• Q12841

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn144, Asn175, and Asn180 ( NX_Q12841 [NX_Q12841-1] )
  Modification sites at PhosphoSitePlus ( Q12841 )
  Glycosylation from GlyConnect

• Protein Refseq
• NP_009016.1

• Function
• Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation.

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