Anti-FSTL1 (clone W24V97) Recombinant Antibody Coupled Liposome (VS-1024-FY99)
CAT#: VS-1024-FY99
Lipid vesicles that bind to anti-FSTL1 antibodies may have significant application prospects in the treatment of gliomas. By targeting tumor cells that express FSTL1, these lipid vesicles can achieve more efficient drug delivery while reducing damage to normal brain tissue. Such carriers help enhance drug bioavailability and improve anti-tumor effects. Future research may focus on in-depth assessments of their safety, efficacy, and clinical applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35251/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35251/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_1_7_selected.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/40815/162380_A_7_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (ASC TERT1, BJ, fHDF/TERT166, HBF TERT88)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000163430-FSTL1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V97
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This represents a recombinant human monoclonal antibody that was designed to specifically target and bind to human FSTL1 (Follistatin-like 1). FSTL1 is a glycoprotein that plays a crucial role in various biological processes, including inflammation, tissue repair, and cellular signaling. By specifically recognizing FSTL1, this antibody can be utilized for a variety of applications in research and therapeutic contexts.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FSTL1
- Introduction
- Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.
- Alternative Names
- FRP; FSL1; OCC1; OCC-1; tsc36; MIR198
- Full Name
- Follistatin Like 1
- Gene ID
- 11167
- UniProt ID
- Q12841
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn144, Asn175, and Asn180 ( NX_Q12841 [NX_Q12841-1] )
Modification sites at PhosphoSitePlus ( Q12841 )
Glycosylation from GlyConnect
- Protein Refseq
- NP_009016.1
- Function
- Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0208MZ | Chicken Anti-FSTL1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4184 | Hi-Affi™ Rabbit Anti-FSTL1 Recombinant Antibody (clone SI261DS) | FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0165-WJ | Mouse Anti-FSTL1 Recombinant Antibody (clone 22B6) | ELISA, FC, WB | Mouse IgG1, κ |
| VS-0224-XY50 | Rabbit Anti-FSTL1 Recombinant Antibody (clone 9) | FC, IF, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0165-WJ-S(P) | Mouse Anti-FSTL1 Recombinant Antibody (clone 22B6); scFv Fragment | ELISA, FC, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0165-WJ-F(E) | Mouse Anti-FSTL1 Recombinant Antibody (clone 22B6); Fab Fragment | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1438 | AbPlus™ Anti-Fstl1 Magnetic Beads (VS-0724-YC1438) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY865 | Anti-FSTL1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC123 | Recombinant Anti-FSTL1 Eliminating Antibody, pH-Sensitive (22B6 var.) | Antigen-Sweeping In Vivo. | Mouse IgG1 kappa |
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